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The NIMH Center for Collaborative Genomic Studies on Mental Disorders was established through the NIMH Human Genetics Initiative in 1998 to leverage and increase the value of human genetic samples and data produced through NIMH funded research.
The NIMH Center, now known as NIMH Repository and Genomics Resource (NIMH-RGR) plays a key role in facilitating psychiatric genetic research by providing a collection of over 150,000 well characterized, high quality patient and control samples from a wide-range of mental disorders. Through concerted and collaborative efforts of the Biologic Core (Rutgers University’s RUCDR Infinite Biologics) and Data Management Core (Washington University in St. Louis and the University of Southern California's Information Sciences Institute), the Center provides the following services:
The NIMH Stem Cell Resource (at RUCDR), a component of NIMH-RGR, provides banking and validation of reprogrammed cells (e.g., iPSCs) and source cells (e.g., fibroblasts) derived from postnatal-to-adult human patients and controls.
The Center is funded by a cooperative agreement, U24MH068457, from the National Institute of Mental Health.
New Manuscripts from PsychENCODE published in Science
The PsychENCODE Consortium is a collaboration between 15 research institutes working to provide an enhanced framework of regulatory genomic elements in individuals with neuropsychiatric disorders. The collaboration has resulted in a comprehensive set of manuscripts published in Science providing new insights into the biology of the developing, adult, and diseased human brain.
Mariani J, Coppola G, Zhang P, Abyzov A, Provini L, Tomasini L, Amenduni M, Szekely A, Palejev D, Wilson M, Gerstein M, Grigorenko EL, Chawarska K, Pelphrey KA, Howe JR, Vaccarino FM. FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders. Cell 2015 Jul 16; 162(2):375-390. PMID: 26186191