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Induced Pluripotent Stem Cells 11.1

Distribution 11.1 for iPSC released data on 111 new subjects from Study 136 (PI: Hallmayer; R01MH100900), Study 146 (PI: Wernig; R01MH092931), Study 159 (PI: Muotri; 1R21MH10777-01), Study 166 (PIs: Tesar, Miller, Findling; R21/R33MH087877), and Study 200 (PI: Morrow; R01MH105442). The collection contains 758 subjects with 571 FCLs, 417 iPSCs, and 8 OEs.

Standard Data & Documentation

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Distribution Bundle [text or excel]: Standard files across disorders, containing demographic, diagnostic, and pedigree information. Sampled (formerly IBX) sample IDs (nrgr_bio_id) and consent level are also provided. Bundle includes data dictionaries.
Study Descriptions.

Additional Data Files

Study 92 Family-Based Genome-Wide Methylation Scan in Neurocognition and Schizophrenia 130

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Study 115 Exploring the Neuronal Phenotype of Autism Spectrum Disorders Using iPSCs 20

Clinical Instruments

Other

Phenotypic Data [text or excel] Includes demographics, diagnoses, body measurements, brain scan data, and summary data from ADI-R, ADOS, Mullen, SRS instruments. Additional subjects for study 115 can be found in the Phelan-McDermid Syndrome (PMS) collection.

Study 116 Cellular and genetic correlates of increased head size in autism spectrum disorder 19

Clinical Instruments

Other

Phenotypic Data [text or excel] Includes item-level data for ADI, ADOS, DAS, Mullen, Vineland, and WISC instruments, along with NDA linking IDs.

Study 117 Autism iPSCs for Studying Function and Dysfunction in Human Neural Development 4

Clinical Instruments

Other

Phenotypic Data [text or excel] Includes demographics, diagnosis, and summary data from ADI, ADOS, and Stanford-Binet

Study 125 Analysis of Glutamatergic Neurons Derived from Patient Specific iPS Cells 13

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Study 127 Target Identification and Validation for Negative Symptoms and Social Cognition in Schizophrenia: A Translational Study 8

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Study 130 Genomics-Guided Characterization of iPS Cells from Common Mental Illnesses 4

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Study 131 Chemical genomic approaches to neurobiology of DISC1 20

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Study 132 NIMH DIRP Protocol 03-M-0035 Screening, Evaluation, Diagnosis, Treatment Optimization and Follow-Up for Childhood Onset Psychiatric Disorders 228

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Study 136 Integrative Molecular and Phenotype Analysis of 22q11.2 Deletion Syndrome 66

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Study 143 Modeling Anorexia Nervosa with Human Pluripotent Stem Cells 8

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Study 144 Modeling Autism with Human Pluripotent Cells 17

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Study 146 Induced Neuronal Cells: A Novel Approach to Study Neuropsychiatric Diseases 9

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Study 158 Modeling schizophrenia using iPSC neurons 11

Clinical Instruments

Other

Phenotypic Data [text or excel] Includes summary data for family history and diagnoses.

Study 159 A chimeric brain model to study human neurological diseases 7

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Study 160 Contrasting causal microRNAs in forebrain and midbrain COS hiPSC neural cells 11

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Study 163 Neuropsychiatric Genome-Scale and RDoC Individualized Domains (N-GRID) 134

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Study 165 Neural development of human induced pluripotent stem cells from schizophrenia patients 4

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

Study 166 Juvenile Onset Schizophrenia iPSCs 14

Clinical Instruments

Other

Study 166 Phenotypic Data [text or excel] s166-misc-phen (n=8) includes medications at time of biopsy and Children’s Global Assessment Score.

Study 200 Mechanisms of Circuit Failure and Treatments in Patient-derived Neurons in Autism 15

Clinical Instruments

Other

Study 200 Phenotypic Data [text or excel] (n=17) includes autism and developmental assessment summary score data.

Study 115 — Exploring the Neuronal Phenotype of Autism Spectrum Disorders Using iPSCs

Phenotypic Data [text or excel] Includes demographics, diagnoses, body measurements, brain scan data, and summary data from ADI-R, ADOS, Mullen, SRS instruments. Additional subjects for study 115 can be found in the Phelan-McDermid Syndrome (PMS) collection.

Study 116 — Cellular and genetic correlates of increased head size in autism spectrum disorder

Phenotypic Data [text or excel] Includes item-level data for ADI, ADOS, DAS, Mullen, Vineland, and WISC instruments, along with NDA linking IDs.

Study 117 — Autism iPSCs for Studying Function and Dysfunction in Human Neural Development

Phenotypic Data [text or excel] Includes demographics, diagnosis, and summary data from ADI, ADOS, and Stanford-Binet

Study 158 — Modeling schizophrenia using iPSC neurons

Phenotypic Data [text or excel] Includes summary data for family history and diagnoses.

Study 166 — Juvenile Onset Schizophrenia iPSCs

Study 166 Phenotypic Data [text or excel] s166-misc-phen (n=8) includes medications at time of biopsy and Children’s Global Assessment Score.

Study 200 — Mechanisms of Circuit Failure and Treatments in Patient-derived Neurons in Autism

Study 200 Phenotypic Data [text or excel] (n=17) includes autism and developmental assessment summary score data.