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March 04, 2019

NRGR Launches New Website

NRGR Launches New Website

December 13, 2018

New Manuscripts from PsychENCODE published in Science

The PsychENCODE Consortium is a collaboration between 15 research institutes working to provide an enhanced framework of regulatory genomic elements in individuals with neuropsychiatric disorders. The collaboration has resulted in a comprehensive set of manuscripts published in Science providing new insights into the biology of the developing, adult, and diseased human brain.

October 11, 2018

22q11.2 Deletion Syndrome Dist. 1.3

22q11.2 Dist. 1.3 includes updated diagnostic data for subjects from study 111.

February 28, 2018

iPSC Dist. 10.0

iPSC Dist. 10.0 includes data from Study 132/Site 502 (PI: Rapoport) and Study 165/Site 369 (PIs: Song, Margolis). In Study 132, there are 44 individuals from 17 families, iPSCs lines, and 44 fibroblasts. In Study 165, there are 4 individuals from 2 families, 9 iPSCs lines, and 0 fibroblasts

February 27, 2018

Anorexia Nervosa Dist. 2.0

Anorexia Nervosa Dist. 2.0 contains 2891 records in 849 families from Study 24 and Study 98, including dummy pedigree connector records. N=1569 subjects have DNA. Version 2.0 adds n=860 new subjects from Study 98 (PI: Klump), n=364 with DNA.

February 21, 2018

SZ Dist. 20.1

Schizophrenia Dist. 20.1 fixed 15 subjects from Study 122 whose dx_study='PNOS'. The dx_nimh should be NSPECCT, not OTHER.

February 15, 2018

SZ Dist. 20.0

Schizophrenia Dist. 20.0 includes new data from Study 92 (PIs: Gur, Nimgaonkar) and Study 122 (PIs: Raventós, Glahn, Almasy). New in this collection for Study 92 are a total of 32 individuals in 32 families (32 subjects have DNA cell lines available; 29 subjects have plasma available). New in this collection for Study 122 are a total of 325 individuals in one family (215 subjects have DNA cell lines available; 209 subjects have plasma available). Also, Study 76 was updated from version 19.0 (9,784 subjects have DNA cell lines available; 5,671 individuals have plasma available). Note: 9,276 subjects in version 19.0 were replaced with 10,069 subjects in version 20.0.

February 08, 2018

Depression Dist. 7.0

Depression Dist. 7.0 adds new data from Study 84 (PATR-Emory CIDAR; PIs: Mayberg, Craighead) and Study 108 (PIs: Meyers, Alexopoulos, Rothschild, Whyte, Flint). This collection contains 12,291 individuals in 6,327 families. 8,039 individuals have DNA cell lines and 883 individuals have plasma available. 460 individuals (231 with DNA cell line and 198 with plasma available) from Study 84 and 177 individuals (177 with DNA cell lines and 130 with plasma available) from Study 108 were added to this distribution.

January 18, 2018

Brain Function Dist. 2.0

Brain Function Dist. 2.0 includes data from Study 58 (PIs: Blangero, Glahn).

December 14, 2017

Study 7 Auxiliary Files Addition

Added Study 7 DSM-IV other diagnoses files under Auxiliary Data.

December 12, 2017

Bipolar Disorder Dist. 12.1

Bipolar Disorder Dist. 12.1 replaced Study 77 (5,042 subjects) with updated version; total 26,285 subjects, 19,579 cell lines, and 4,374 had plasma available.

November 30, 2017

ADHD Dist. 1.3

ADHD Dist. 1.3 conforms the dataset to the standard NRGR schema column order; no new data.

November 16, 2017

Study 7 Auxiliary Files Addition

Added Study 7 DSM-IV diagnoses files under Auxiliary Data.

November 08, 2017

SZ Dist. 19.0

Schizophrenia Dist. 19.0 includes new data from Study 67 (PIs: Escamilla, Raventos). New in this collection are a total of 1,070 individuals in 175 families (523 individuals have DNA cell lines available; 0 individuals have plasma available).

November 01, 2017

Bipolar Disorder DIGS Update

Added cleaned version of the DIGS interview files.

November 01, 2017

Depression DIGS Update

Added cleaned version of the DIGS interview files.

November 01, 2017

Schizophrenia DIGS Update

Added cleaned version of the DIGS interview files.

October 25, 2017

iPSC Dist. 9.0

iPSC Dist. 9.0 includes data from Study 127/Site 717 (PIs: Hahn, Brodkin). There are 8 individuals from 8 families, 8 iPSCs (EPOE) lines, and 8 fibroblasts.

October 24, 2017

Controls Dist. 8.5

Controls Dist. 8.5 replaced Study 77 with updated version and excluded DNG subjects for a total of 20,232 subjects (9,233 subjects have plasma) in this version.

October 23, 2017

RDoC Dist. 1.1

Added the pedigree drawings for Study 120.

October 11, 2017

ADHD Dist. 1.2

ADHD Dist. 1.2 conforms the dataset to the standard NRGR schema.

September 18, 2017

Bipolar Disorder Dist. 12.0

Bipolar Disorder Dist. 12.0 includes new data from Study 48 Part 1 (PIs: McMahon, DePaulo, Gershon; Application # NA_00038551) and Study 140 (PIs: Freimer, Jaramillo, Macaya, Raventos; 3R01MH095454-02S1). Study 48 Part 1 added new data for 701 subjects and Study 140 added new data for 349 subjects.

September 05, 2017

Alzheimer's Disease Dist. 3.2

Alzheimer's Disease Dist. 3.2 standardized variables in distribution file.

August 29, 2017

Depression Dist. 6.2

Depression Dist. 6.2 added 2 new variables and updated consent status for some subjects in the standard distribution file.

August 15, 2017

Fear & Anxiety Dist. 1.2

Fear and Anxiety Dist. 1.2 standardized variables in distribution file and Study 61 and 62 controls file.

August 15, 2017

Suicide Dist. 1.3

Suicide Dist. 1.3 standardized variables in distribution file.

August 14, 2017

Compulsive Hoarding Dist. 1.3

Compulsive Hoarding Dist. 1.3 standardized variables in distribution file and Study 93 controls file.

August 14, 2017

PMS Dist. 1.3

PMS Dist. 1.3 standardized variables in distribution file.

August 08, 2017

SZ Dist. 18.01

Schizophrenia Dist. 18.01: 3,106 subjects from dbGaP GAIN (phs000021) and non-GAIN (phs000167) are consented for 'GRU'. If cell_id='NULL' and DX_NIMH='UNKNOWN', then consent set to 'NULL'. 15,465 subjects were updated and consented to 'NULL'.

July 31, 2017

Controls Dist. 8.4

Controls Dist. 8.4 fixes consent value to GRU and replaces Study 76 with updated version.

July 19, 2017

Bipolar Disorder Dist. 11.4

Bipolar Disorder Dist. 11.4 standardized variables in distribution file.

July 19, 2017

Brain Function Dist. 1.3

Brain Function Dist. 1.3 standardized variables in distribution file.

July 18, 2017

22q11.2 Deletion Syndrome Dist. 1.2

22q11.2 Deletion Syndrome Dist. 1.2 standardized variables in distribution file.

July 18, 2017

NTR Dist. 2.2

NTR Dist. 2.2 standardized variables in distribution file.

July 18, 2017

OCD Dist. 2.6

OCD Dist. 2.6 standardized variables in distribution file.

July 18, 2017

PTSD Dist. 1.2

PTSD Dist. 1.2 standardized variables in distribution file.

July 18, 2017

RDoC Dist. 1.1

RDoC Dist. 1.1 standardized variables in distribution file.

July 17, 2017

SZ Dist. 18.0

Schizophrenia Dist. 18.0 includes new data from Study 90 (PIs: Riley, Corvin, Kendler, Gill, et al.). New in this collection are a total of 562 individuals (562 individuals have DNA cell lines available; 558 individuals have plasma available). Also, based on updated consent information, the detail cell_id and diagnosis information was removed from SZ Dist. 17.2 for 13 subjects of COGS1 (Study 27, site 126).

June 12, 2017

Controls Dist. 8.3

Controls Dist. 8.3 standardized variables.

June 12, 2017

iPSC Dist. 8.0

iPSC Dist. 8.0 includes data from Study 131/Site 317 (PIs: Tsai, Cohen, Perlis). There are 20 individuals from 20 families, 20 iPSCs, and 0 fibroblasts.

June 12, 2017

Trichotillomania Dist. 1.3

Trichotillomania Dist. 1.3 standardizes variables.

June 12, 2017

Tourette Syndrome Dist. 1.4

Tourette Syndrome Dist. 1.4 includes updates in May 2017 and standardized variables. Total of 2,981 subjects, 2,646 subjects have DNA cell lines available; 2,208 subjects have plasma available.

May 22, 2017

ADHD Dist. 1.1

ADHD Dist. 1.1 added the variable dist for distribution number.

May 22, 2017

SZ Dataset 34 Addition

NIMH Study 9; PIs: Weinberger, Egan, Straub

May 15, 2017

Anorexia Nervosa Dist. 1.02

Anorexia Nervosa Dist. 1.02 added the variable dist for distribution number.

May 10, 2017

SZ Dataset 33 Addition

NIMH Study 90; A genomewide association study of schizophrenia in Ireland (PIs: Riley, Corvin, Gill, Kendler)

May 08, 2017

Autism Dist. 14.1

Autism Dist. 14.1 added the variable dist for distribution number.

April 26, 2017

SZ Dist. 17.2

Schizophrenia Dist. 17.2 added new data from NIMH Study 91 (PI: Goldstein) that was previously released in SZ Dist. 11.0 in order to keep consistent with the subjects submitted to dbGaP (phs000682). New in this addition are a total of 127 individuals.

April 20, 2017

22q11.2 Deletion Syndrome Dist. 1.1

22q11.2 Deletion Syndrome Dist. 1.1 added the variable dist for distribution number.

April 20, 2017

Fear & Anxiety Dist. 1.1

Fear and Anxiety Dist. 1.1 added the variable dist for distribution number.

April 20, 2017

NTR Dist. 2.1

NTR Dist. 2.1 added the variable dist for distribution number.

April 20, 2017

Compulsive Hoarding Dist. 1.2 and Trichotillomania Dist. 1.2

Compulsive Hoarding Dist. 1.2 and Trichotillomania Dist. 1.2 added the variable dist for distribution number.

April 20, 2017

PMS Dist. 1.2

PMS Dist. 1.2 added the variable dist for distribution number.

April 20, 2017

PTSD Dist. 1.1

PTSD Dist. 1.1 added the variable dist for distribution number.

April 20, 2017

Suicide Dist. 1.2

Suicide Dist. 1.2 added the variable dist for distribution number.

April 20, 2017

Tourette Syndrome Dist. 1.3

Tourette Syndrome Dist. 1.3 added the variable dist for distribution number and fixed cell_id for 4 subjects.

April 18, 2017

BP Dataset 31 Addition

NIMH Study 71 genotype data

April 05, 2017

RDoC Dist. 1.0

RDoC Dist. 1.0 includes data from Study 120/Site 500 (PIs: Zald, Lahey; Tennessee Twin Study Wave 2). There are 396 individuals in RDocDB and 414 dummy parents for a total of 820 individuals from 212 families, 396 with cell lines and 256 have plasma available.

March 23, 2017

Alzheimer's Disease Dist. 3.1

Alzheimer's Disease Dist. 3.1 added the variable dist for distribution number.

March 23, 2017

Bipolar Disorder Dist. 11.3

Bipolar Disorder Dist. 11.3 added the variable dist for distribution number.

March 23, 2017

Brain Function Dist. 1.2

Brain Function Dist. 1.2 added the variable dist for distribution number.

March 23, 2017

Controls Dist. 8.2

Controls Dist. 8.2 added the variable dist for distribution number.

March 23, 2017

Depression Dist. 6.1

Depression Dist. 6.1 added the variable dist for distribution number.

March 23, 2017

OCD Dist. 2.5

OCD Dist. 2.5 added the variable dist for distribution number.

March 23, 2017

SZ Dist. 17.1

Schizophrenia Dist. 17.1 added the variable dist for distribution number.

March 09, 2017

Depression Dist. 6.0

Depression Dist. 6.0 adds new data from Study 83 (IRL GREY; PIs: Reynolds, Lenze, Mulsant). This collection contains 11,654 individuals in 5,690 families. 7,631 individuals have DNA cell lines and 555 individuals have plasma available. 437 individuals (437 with DNA cell line and 380 with plasma available) from Study 83 were added to this distribution.

March 09, 2017

Compulsive Hoarding Dist. 1.1

Compulsive Hoarding Dist. 1.1 standardizes variables.

March 08, 2017

iPSC Dist. 7.0

iPSC Dist. 7.0 includes data from Study 130/Site 433 (PIs: Haggarty, Perlis) and Study 163/Site 416 (PIs: Kohane, Perlis). In Study 130, there are 4 individuals from 4 families, 10 iPSCs, and 4 fibroblasts. In Study 163, there are 134 individuals from 134 families, 110 iPSCs, and 24 fibroblasts.

March 07, 2017

Controls Dist. 8.1

Controls Dist. 8.1 standardized variables.

February 28, 2017

Autism Dataset 5 Addition

Study 35, CEL and CNV files, n=9

February 23, 2017

22q11.2 Deletion Syndrome

22q11.2 Deletion Syndrome Dist. 1.0 includes data from NIMH Study 111 (PI: Kates). Included in this collection are a total of 64 individual cases; all 64 subjects with cell_line and 58 have plasma available.

February 23, 2017

SZ Dataset 32 Addition

Partial exome, 38 genes, Study 76 (PIs: Malaspina, Kranz, Chao)

January 25, 2017

iPSC Dist. 6.0

iPSC Dist. 6.0 includes data from Study 92/Sites 322-323 (PIs: Gur, Nimgaonkar) and Study 160/Site 504 (PI: Brennand). In Study 92, there are 130 individuals from 130 families, iPSCs, and 174 fibroblasts. In Study 160, there are a total of 41 iPSCs, fibroblasts. Also, 11 cases from Study 132/Site 499 (PI: Rapoport) were updated with iPSCs; 11 controls.

December 22, 2016

SZ Dist. 17.0

Schizophrenia Dist. 17.0 includes new data from Study 94 (CIAC: PIs: Sullivan, et al.) and released genotype data for Study 94 in SZ Dataset 31.
New in this collection are a total of 482 individuals in 482 families from Study 94 (270 individuals have DNA cell lines available; 251 individuals have plasma available). Also released was the genotype data for Study 94 in SZ Dataset 31.

November 16, 2016

Tourette Syndrome Dist. 1.2

Tourette Syndrome Dist. 1.2 corrected several genders.

November 01, 2016

PTSD Dist. 1.0

Post-traumatic Stress Disorder (PTSD) Dist. 1.0 includes data from Study 87; Sites 299, 300, 313 and 314 (PIs: Mayberg, et al.). There are a total of 108 subjects from 108 families (108 subjects with cell lines; 107 have plasma available). Clinical data is currently unavailable.

October 26, 2016

Tourette Syndrome Dist. 1.1

Tourette Syndrome Dist. 1.1 corrected dx from ChronicTic to TDChronicTic.

October 25, 2016

Trichotillomania Dist. 1.1

Trichotillomania Dist. 1.1 standardizes variables.

October 13, 2016

Bipolar Disorder Dist. 11.2

Bipolar Disorder Dist. 11.2 standardized variables in distribution file.

October 13, 2016

Tourette Syndrome Dist. 1.0

Tourette Syndrome Dist. 1.0 includes data from Study 106/Sites 600-609 (PIs: Tischfield, Heiman, State, et al.). There are 2,981 subjects from 780 families; 2,647 subjects with cell lines and 2,152 subjects have plasma.

October 12, 2016

Autism Dist. 14.0

Autism Dist. 14.0 includes data from NRGR Study 56 (PI: Thurm), Study 60 (PI: Piven), Study 86 (PI: Haines), and Study 112 (PI: Devinsky). This collection contains 5,285 families and 21,466 individuals of which 18,822 have DNA cell lines. New in this collection are a total of 495 families (1,840 individuals, 1,646 with DNA). The Autism Dist. 14.0 Control dataset has the same format as the main distribution file and contains 254 families and 765 individuals of which 516 have DNA cell lines.

October 11, 2016

CommonMind Consortium Dist. 1.2

CommonMind Consortium Knowledge Portal Release 1.2 data is now available.

September 12, 2016

OCD Dist. 2.4

OCD Dist. 2.4 standardizes distribution file.

August 31, 2016

PsychENCODE Consortium Dist. 2.0

PsychENCODE Consortium data release for August 2016.

July 11, 2016

iPSC Dist. 5.0

iPSC Dist. 5.0 includes data from Study 158/Site 361 (PIs: Brennand, Gage). There are 11 individuals from 10 families, 13 iPSCs, and 0 fibroblasts for a total of 280 subjects.

July 05, 2016

Brain Function Dist. 1.1

Brain Function Dist. 1.1 standardizes variables in Dist. 1.0.

June 02, 2016

PMS Dist. 1.1

PMS Dist. 1.1 standardizes variables in Dist. 1.0 and adds auxiliary files.

April 27, 2016

SZ Dist. 16.0

Schizophrenia Dist. 16.0 includes new data from Study 72 (PROACTIVE: PIs: Miller, et al.) and Study 104 (ACLAIMS; PIs: Stroup, et al.). New in this collection are a total of 363 individuals in 363 families from Study 72 and Study 104 (360 individuals have DNA cell lines available; 176 individuals have plasma available).

March 10, 2016

Alzheimer's Disease Dist. 3.0

Alzheimer's Disease Dist. 3.0 added 185 subjects from Study 17/Site 75 (CATIE-AD).

February 03, 2016

SZ Dist. 15.0

Schizophrenia Dist. 15.0 includes new data from Study 82 (PIs: Ming T. Tsuang, Stephen J. Glatt, et al.). New in this collection are a total of 9,097 individuals in 3,003 families.

February 02, 2016

PsychENCODE Consortium Dist. 1.0

PsychENCODE Consortium data access information was added.

December 10, 2015

Fear & Anxiety Dist. 1.0

Fear and Anxiety Dist. 1.0 includes data from Study 61/Site 137 (PIs: Weissman, et al.) and Study 62/Site 138 (PIs: Fyer, et al.). This new collection contains 320 cases from Study 61 (no plasma) and 60 controls from Study 61 plus 197 subjects (no dx) from Study 62 (no plasma).

December 08, 2015

Suicide Dist. 1.1

Suicide Dist. 1.1 reordered and renamed variables in the distribution file.

November 19, 2015

Bipolar Disorder Dist. 11.1

Bipolar Disorder Dist. 11.1 made corrections for dx variable: 1351 subjects from Study 77 whose dx code should be SAB not SABP. Adjusted variables in standard and auxiliary files.

November 19, 2015

Suicide Dist. 1.0

Suicide Dist. 1.0 includes data from Study 80/Sites 288-290 (PIs: Mann, Turecki, Rujesca). There are 181 subjects including 159 controls and 22 probands, 3 have plasma.

November 02, 2015

Bipolar Disorder Dist. 11.0

Bipolar Disorder Dist. 11.0 includes new data from Study 75 (PIs: Nierenberg, Calabrese, Iosifescu, et al; R01HS01937101). Study 75 added new data for 193 subjects.

October 07, 2015

Bipolar Disorder Dist. 10.4

Bipolar Disorder Dist. 10.4 fixed d4dx5 for subject 174-1251-001 from 303.90 to 301.9.

October 01, 2015

SZ Dist. 14.0

Schizophrenia Dist. 14.0 includes new data from Study 27 (PI: David Braff), Study 68 (PI: Lynn DeLisi), and Study 85 (PI: Lynn DeLisi).

September 22, 2015

Autism Dist. 13.0

Autism Dist. 13.0 includes new data from NIMH Study 39 (PI: Brzustowicz), Study 63 (PI: Cook), and Study 69 (PI: Minshew). This collection contains 4,793 families and 19,359 individuals of which 17,189 have DNA cell lines. New in this collection are a total of 360 families (1,303 individuals, 1,059 with DNA).

September 16, 2015

CommonMind Consortium Dist. 1.1

CommonMind Consortium Knowledge Portal Release 1.1 data is now available.

July 15, 2015

Trichotillomania Dist. 1.0

Trichotillomania Dist. 1.0 adds new data from Study 134/Site 508 (PI: Keuthen) and includes 513 individuals from 295 families and 419 individuals have cell lines.

July 15, 2015

SZ Dataset 30 Addition

Results of Next Generation Sequencing of Two Genes (EGR3 and ARC) in Schizophrenia from Dr. Amelia Gallitano, multiple studies and controls.

July 06, 2015

Bipolar Disorder Dist. 10.3

Bipolar Disorder Dist. 10.3 fixed DSM-IV/DSM-III-R coding except for codes ending with x, added variables idc9 dx, icd9 dx age onset, and icd9 dx confidence.

June 28, 2015

Bipolar Disorder Dist. 10.2

Bipolar Disorder Dist. 10.2 fixed none-standard DSM-IV coding plus posted standard and auxiliary files.

June 09, 2015

Compulsive Hoarding Dist. 1.0

Compulsive Hoarding Dist. 1.0 adds new data from Study 93/Site 245 (PI: Mathews) and includes 102 individuals from 60 case families and 41 individual controls.

May 12, 2015

Bipolar Disorder Dist. 10.1

Bipolar Disorder Dist. 10.1 fixed none-standard DSM-IV coding.

May 07, 2015

CN Dataset 3

SICCA NIMH only (Illumina 2.5M SNPs) added to Controls Dist. 8.0.

April 23, 2015

Autism Dist. 12.01

Autism Dist. 12.01 added new psychiatric instrument data from NIMH Study 50 (PI: Coon) on the same set of subjects as Autism Dist. 12.0.

April 23, 2015

iPSC Dist. 4.0

iPSC Dist. 4.0 includes data from Study 143/Site 408 (PI: Muotri) and Study 144/Site 738 (PIs: Muotri, Duvvuri). In Study 143, there are 8 individuals from 8 families, 21 iPSCs, and 13 fibroblasts, and in Study 144, there are 17 individuals from 17 families, 43 iPSCs, and 23 fibroblasts for a total of 269 individuals. Also, updated data from Study 116 and Study 125.

March 23, 2015

Controls Dist. 8.0

Controls Dist. 8.0 includes new data for unaffected subjects from Study 76 and Study 77.

March 23, 2015

SZ Dist. 13.0

Schizophrenia Dist. 13.0 includes new data for 9,276 individuals in 8,295 families from Study 76 (PI: Carlos Pato).

March 19, 2015

Bipolar Disorder Dist. 10.0

Bipolar Disorder Dist. 10.0 includes new data from Study 77-Part 1 (PIs: Smoller, Skar, Pato, et al; R01MH085542) and Study 123 (PI: Swartz; R01MH084831). Study 77-Part 1 added 4,493 subjects and Study 123 added 38 subjects.

March 19, 2015

CommonMind Consortium

CommonMind Consortium data access information was added.

March 17, 2015

Brain Function Dist. 1.0

Brain Function Dist. 1.0 includes data from Study 109 (PI: Milham).

January 26, 2015

SZ Dist. 12.01

SZ Dist. 12.01 updates the auxiliary files within the addition of plasma variable.

January 22, 2015

Bipolar Disorder Dist. 9.1

Bipolar Disorder Dist. 9.1 updates the distribution files with the addition of plasma variable.

January 22, 2015

Controls Dist. 7.05

Controls Dist. 7.05 updates the distribution files with the addition of plasma variable.

January 22, 2015

OCD Dist. 2.3

OCD Dist. 2.3 updates the distribution files with the addition of plasma variable.

December 17, 2014

SZ Dist. 12.0

SZ Dist. 12.0 includes new data for 830 case individuals and 1,478 controls from Study 9 (PIs: Weinberger, Straub). Diagnoses were obtained from medical records and clinical charts, no DIGS or SCID were performed for Study 9.

October 17, 2014

Depression Dist. 5.0

Depression Dist. 5.0 adds new data from Study 20 (TADS [PI: March] and SOFTAD [Curry]) and Study 73 (CO-MED [PI: Trivedi]). This collection contains 11,217 individuals in 5,253 families. 7,194 individuals have DNA cell lines and 175 individuals have plasma available. 171 individuals from Study 20 and 478 individuals from Study 73 were added to this distribution.

September 26, 2014

OCD Dist. 2.2

OCD Dist. 2.2 updates Study 66 with the latest blood file. Added 8 pedigrees and removed one. Total 5,656 individuals in 1,490 families.

September 25, 2014

Bipolar Disorder Dist. 9.0

Bipolar Disorder Dist. 9.0 includes data from Study 71 (PIs: Freimer, Macaya, el al; R01MH075007) and added 139 new subjects (143 subjects had a change to dx) from Study 1.

August 28, 2014

OCD Dist. 2.1

OCD Dist. 2.1 fixes 2 subject's cell_ids and ind_ids (in blood file).

July 17, 2014

iPSC Dist. 3.0

iPSC Dist. 3.0 includes data from Study 132/Site 499 (PI: Rapoport). There are 184 individuals from 59 families, iPSCs, and 184 fibroblasts for a total of 242 individuals.

June 19, 2014

Autism Dist. 12.0

Autism Dist. 12.0 includes new data from Study 44 (PI: Sutcliffe) and Study 50 (PI: Coon). This collection contains 4,434 families and 18,059 individuals of which 16,130 have DNA cell lines. New in this collection are a total of 182 families (564 individuals, 439 with DNA) from Study 44 (n=397 individuals) and Study 50 (n=167 individuals). The new data from Study 50 represents an update to the original deposit in Autism Dist. 9.0 (as Study 50) and in Autism Dist. 10.0 (as a component study of Study 65/TASC/AGP).

May 28, 2014

Bipolar Disorder Dist. 8.0

Bipolar Disorder Dist. 8.0 includes new data from Study 55 (PIs: Nurnberger, Kastelic, McInnis, Reich, Glowinski; R01MH068009). There are 533 subjects from 210 families in Study 55 with 325 subjects with DNA available.

May 20, 2014

Depression Dist. 4.0

Depression Dist. 4.0 contains 10,568 individuals in 4,606 families from Studies 7 (GenRED I), 52 (GenRED II), 18 (STAR*D), and 88 (Depression Genes Network [DGN]). 6,545 individuals have DNA cell lines. 463 cases from Study 88 were added and 459 controls were collected for this study.

April 21, 2014

DP Dataset 7 Addition

Levinson RNA Sequencing data from Study 88/Site 621

April 15, 2014

PMS Dist. 1.0

PMS Dist. 1.0 includes data from Study 115/Sites 726 and 734 (PIs: Hallmayer, Dolmetsch; Phelan McDermid Foundation). There are 165 individuals from 55 families. There are 55 probands.

March 31, 2014

Autism Dataset 4 Addition

Study 65 / TASC GWAS Data

March 20, 2014

iPSC Dist. 2.0

iPSC Dist. 2.0 includes data from Study 116/Site 727 (PI: Vaccarino). There are 19 individuals from 6 families, 25 iPSCs, and 19 fibroblasts for a total of 58 individuals.

February 20, 2014

iPSC Dist. 1.0

iPSC Dist. 1.0 includes data from Study 115/Sites 726 and 734 (PIs: Hallmayer, Dolmetsch; Phelan McDermid Foundation), Study 117/Site 728 (PI: Loring; Fragile X-Autism), and Study 125/Sites 392-393 (PIs: Lachman, Rapoport; 22q11 Deletion Syndrome). There are 20 individuals from 17 families, 4 iPSCs, and 20 fibroblasts in Study 115. There are 4 individuals from 4 families, 8 iPSCs, and 0 fibroblasts in Study 117. There are 15 individuals from 15 families, 16 iPSCs, fibroblasts in Study 125 for a total of 39 individuals.

February 11, 2014

SZ Dist. 11.01

The NPI algorithm was updated, variables NPI and NPISO were removed, and a variable DX (phenotype status) was added in the auxiliary file.

December 05, 2013

SZ Dataset 28 Addition

Dr. Debby Tsuang Exome data from Sites 30 and 32 (Study 0)

September 30, 2013

SZ Dataset 27 Addition

CATIE Genome-Wide Association Data

September 09, 2013

SZ Dist. 11.0

SZ Dist. 11.0 includes new data for 99 families from Study 91 (PIs: Goldstein, McEvoy, Need). Diagnoses were obtained from clinical charts, no DIGS or SCID were performed for Study 91.

August 21, 2013

Bipolar Disorder Dist. 7.01

Bipolar Disorder Dist. 7.01 includes updated data from Study 49 based on the data harvest revised as of Dec. 2012 and genotyped data received June 2013. 6329 subjects from 803 families were in Study 49. 2681 of 6329 subjects have DNA available.

July 30, 2013

BP Dataset 29 Addition

BP Dataset 29 Addition (SNP Linkage Genotyping Data). Raw and partially cleaned data from Michael Escamilla for NIMH Study 49. Cleaned genotyping data was added on August 14, 2013.

May 08, 2013

OCD Dist. 2.0

OCD Dist. 2.0 includes data from Study 66 (sites 240-244). There are 1,156 new families and 3,921 new individuals for a total of 1,483 families and 5,634 individuals.

April 23, 2013

Autism Dist. 11.0

Autism Dist. 11.0 includes new data from Study 79 (aka Autism Consortium, Boston Autism Consortium, PIs: Kunkel, Walsh). This collection contains 4,278 families and 17,496 individuals of which 15,673 have blood samples. New in this collection are 316 families (1,169 individuals, 1,048 with blood) from Study 79.

February 19, 2013

SZ Dataset 29 Addition

Sweden Schizophrenia Study

February 07, 2013

BP Dataset 28 Addition

BP Dataset 28 Addition (STEP-BD)

January 15, 2013

SZ Dist. 10.0

SZ Dist. 10.0 includes new data for 260 families from Study 59 (PI: Ophoff). Also, 262 controls were collected for this study.

October 25, 2012

Autism Dist. 10.0

Autism Dist. 10.0 includes new data from Study 65 (aka TASC = The Autism Simplex Collection, PI: Gallagher). This new collection contains 3,962 families and 16,327 individuals of which 14,625 have blood samples. There are 1,339 families (4,298 individuals) from TASC, which represents approximately 80% of the total TASC data. The remaining 20% is undergoing preparation by the TASC DCC and will be available at a later date.

October 15, 2012

Bipolar Disorder Dist. 7.0

Bipolar Disorder Dist. 7.0 includes new data from Study 49 based on the data harvest as of June 2012. 7730 subjects from 755 families were added, 2541 of 7730 subjects have DNA available.

September 11, 2012

Controls Dist. 7.04

Controls Dist. 7.04 adds gender of Study 19/Site 88 subjects.

August 06, 2012

BP Dataset 27 Addition

Chromosomes 1-22 (SureGene - Custom Illumina iSelect chip containing 7,584 SNPs)

August 06, 2012

SZ Dataset 26 Addition

Chromosomes 1-22 from multiple studies (SureGene)

June 25, 2012

SZ Dataset 25 Addition

Full Genome Screen from multiple studies (PI: Anna Need)

May 16, 2012

SZ Dist. 9.0

SZ Dist. 9.0 includes new data for 193 families from Study 42 (Pulver).

April 24, 2012

Autism Dist. 9.0

Autism Dist. 9.0 includes new data from Study 50 (PI: Coon, Utah families). This study contains 2,930 families and 12,990 individuals of which 11,496 have blood samples.

March 22, 2012

NTR Dist. 2.0

NTR Dist. 2.0 includes 9,123 subjects with Rutgers IDs and their families from Study 78 (number of families=3,655; total=11,900 subjects).

March 14, 2012

DP Dataset 6 Addition

STAR*D/Study 18

February 07, 2012

Anorexia Nervosa Dist. 1.01

Anorexia Nervosa Dist. 1.01 contains 2,031 records in 412 families from Study 24, including dummypedigree connector records. N=1205 subjects have blood samples. Version 1.01 updates the Version 1.0 data by conforming the data to a standard format and correcting errors.

February 07, 2012

Depression Dist. 3.02

Depression Dist. 3.02 contains 10,105 records in 4,141 families from Studies 7, 52, and 18 (STAR*D). 8,163 records in 2,199 families were in the previous distribution (version 3.01), 1,942 records in 1,942 families from Study 18 (STAR*D/Site 77).

October 25, 2011

Bipolar Disorder Dist. 6.02

Added auxiliary files for Bipolar Disorder Dist. 6.02 - list of subjects in GWAS (GAIN and non-GAIN).

October 07, 2011

Depression Dist. 3.01

Depression Dist. 3.01 corrects errors in the Study 52 DIGS and auxiliary files; otherwise, it is identical to Dist. 3.0.

August 25, 2011

Controls Dist. 7.03

Controls Dist. 7.03 restores 3 records that were in Dist. 5.0 and were removed from Dist. 6.01-7.02 because of known race or sex discrepancy.

July 07, 2011

Controls Dist. 7.02

Controls Dist. 7.02 added diagnostic algorithms and updated phenotypic data.

June 09, 2011

Autism Dist. 8.0

Autism Dist. 8.0 includes new data from Study 35 (Pericak-Vance, Molecular and Genetic Epidemiology of Autism). This study adds 409 affected subjects plus related family members for a total n=1337 of which n=1218 have blood samples.

February 18, 2011

Bipolar Disorder Dist. 6.02

Dist. 6.02 includes updates to Study 40 subjects based on the final data harvest. An additional 210 subjects are included. Of the 240 subjects, 99 did not meet the diagnostic criteria for Bipolar Model I, II, or III categories, but were included for consistency with the GAIN analysis.

January 24, 2011

Depression Dist. 3.0

Depression Dist. 3.0 contains 8,163 records in 2,199 families from Study 7 (GenRED I) and Study 52 (GenRED II), including dummy pedigree connector records and counting singletons as a family. Dist 3.0 adds Study 52 subjects to the Study 7 data.

January 03, 2011

Bipolar Disorder Dist. 6.01

a) Site 78 individual ids were revised for consistency with genotype files.
b) Variable length for dx variables d3rdx1-d3rdx8 were extended to correct truncating.
c) A flag was added for subjects with DIGS phenotype data.
d) Study number revised for sites 10-13 to Study=0.
e) Father_id 11-99002 was replaced as 11-10049.
f) Father_id 22-10159 dropped due to IRB issue. Re-assigned as 22-10199.
g) Cell_id for individual id 24-10222 corrected to 00C02884 per notification from Rutger's Cell and DNA Repository.

December 28, 2010

Controls Dist. 7.01

Controls Dist. 7.01 restores 49 records that were on Dist. 5.0 and inadvertently omitted from Dist. 6.0 and 7.0.

November 15, 2010

Autism Dist. 7.01

Autism Dist. 7.01 excludes one family (202-2922) with a subject who failed to meet Autism Spectrum Disorder criteria (per AGRE clinical staff).

November 10, 2010

BP Datasets 21-26 Added

BP Dataset 21 (G72Reseq), BP Dataset 22 (TRAR), BP Dataset 23 (Choline), BP Dataset 24 (Circadian 1 & 2), BP Dataset 25 (Neurotrans), BP Dataset 26 (Neurotrans)

November 02, 2010

DP Dataset 4.01

Added information for controls

October 28, 2010

Autism Dist. 7.0

Autism Dist. 7.0 includes new data from AGRE. This study adds 724 affected subjects plus related family records (2069). It also includes updates to subjects in the Distribution 6.0 data.

October 12, 2010

SZ Dataset 24 Addition

Full Genome Screen from NIMH Study 22 - PAARTNERS

October 01, 2010

SZ Dataset 23 Addition

Full Genome Screen from NIMH Study 13 - 2005 Linkage Data

September 30, 2010

SZ Dataset 22 Addition

Full Genome Screen from NIMH Study 13 - 2003 Linkage Data

September 13, 2010

SZ Dataset 21 Addition

Full Genome Screen from NIMH Study 15, 386 Microsatellite Markers and 93 SNP Markers

August 24, 2010

DP Dataset 5 Addition

88 GenRED Markers

June 11, 2010

DP Dataset 4 Addition

GenRED

May 13, 2010

ADHD Dist. 1.0

ADHD Dist. 1.0 contains 5,734 records in 1,331 families from Study 25.

April 09, 2010

SZ Dataset 11.01

Updated files

April 05, 2010

BP Dataset 17 Addition

STEP-BD Genotypic Data (STEP-BD / Chr6)

April 01, 2010

BP Dataset 16 Addition

BP Dataset 16 Addition(STEP-BD)

March 31, 2010

BP Dataset 16 Addition

STEP-BP Genotypic Data

March 30, 2010

AD Dataset 20 Addition

Full Genome Screen / Total genotypes = 78,408

March 30, 2010

SZ Dataset 1.02

Documentation changed substantially in that the missing markers on the maps for Chr 9 and 15 are documented and a proposed new marker order is included. The original map was not modified.

March 17, 2010

SZ Dataset 1.01

Added Chr 22 map file

March 10, 2010

BP Dataset 20 Addition

Full Genome Screen / Total genotypes = 148,512

March 10, 2010

BP Dataset 15 Addition

Ankyrin 3 (ANK3)

March 09, 2010

SZ Dataset 20 Addition

Full Genome Screen / Total genotypes = 68,016

December 30, 2009

Schizophrenia Dist. 8.0

Schizophrenia Dist. 8.0 includes new data for 138 families from Study 23.

November 01, 2009

Controls Dist. 7.0

Controls Dist. 7.0 includes new data for 105 unaffected adults from Study 23.

September 30, 2009

Schizophrenia Dist. 7.0

Schizophrenia Dist. 7.0 includes new data for 573 families from Study 22.

September 25, 2009

Bipolar Disorder Dist. 6.0

Bipolar Disorder Dist. 6.0 includes 6,080 independent cases, including 1,829 new cases from the STEP-BD longitudinal study. It also includes 871 sib pairs with DNA from the previous distribution.

July 01, 2009

BP Dataset 11 Phase 2 Addition

Pritzker 550K Illumina SNPs Phase 2

June 22, 2009

Bipolar Disorder Dist. 5.0

Bipolar Disorder Dist. 5.0 adds over 3,700 cases for Study 40, most of which have no parents since it was a case-control study design (analysis compared affected to controls). There are 187 trios but pedigree drawings are not necessary for them. Study 40 used a new form of the DIGS, version 4.0, therefore, we had to add new separate DIGS files and documentations.

June 05, 2009

SZ Dataset 19 Addition

240 Markers on Chromosomes 1-6, 8-13, 22, X and Y, 42 genes were included

May 28, 2009

BP Dataset 14 Addition

Chromosomes 1-6, 8-13, 22, X, Y

March 17, 2009

NIMH_ID and GAIN_ID Cross-Reference

This file provides the NIMH_ID and GAIN_ID for subjects included in the GAIN (Genetic Association Information Network) bipolar disorder study.

March 16, 2009

OCD Dist. 1.0

OCD Dist. 1.0 includes data from Study 16 (sites 64-69). There are 327 families and 1,713 individuals.

February 27, 2009

Anorexia Nervosa Dist. 1.0

Anorexia Nervosa Dist. 1.0 contains 412 families from Study 24

January 24, 2009

STAR*D Mapping

Addition of STAR*D IDs mapping text file

November 05, 2008

Depression Dist. 2.0

Depression Dist. 2.0 includes the addition of the STAR*D clinical data and genotypes.

October 24, 2008

NIMH_ID and GAIN_ID Link

Addition of link between NIMH_ID and GAIN_ID in Controls Dist. 6.12.

September 04, 2008

DP Dataset 1 Addition

GenRED 92 SNPs markers

September 01, 2008

Autism Dist. 6.0

Autism Dist. 6.0 includes new data from Study 41. This study adds 169 affected subjects plus related family records (514 total). It also includes a few updates to Dist. 5.0 data.

August 08, 2008

Controls Dist. 6.12

Controls Dist. 6.12 omits 24 records where genotyped race values were inconsistent with reported phenotypic values, and includes one new record with phenotypic information.

July 31, 2008

SZ Dataset 18 Addition

Total of 648 SNPs Markers, 14 genes (RGS4, DISC1, DTNBP1, STX7, TAAR6, PPP3CC, NRG1, DRD2, HTR2A, DAOA, AKT1, CHRNA7, COMT, ARVCF) were included for April 08 AJP paper from MGS project (Study 29)

July 21, 2008

SZ Dataset 13

Addition of text version of data files

July 17, 2008

BP Dataset 13 Addition

Chromosomes 5q and 8p / bipolar disorder, GRIA1

July 09, 2008

Schizophrenia Dist. 6.0

Schizophrenia Dist. 6.0 includes new data for 3,848 families from Study 29. Families from Site 17 of Study 13 were excluded from Dist. 6.0.

June 01, 2008

Autism Dist. 5.0

Autism Dist. 5.0 includes contributions from Version 4.1 sites, some of which has been updated, as well as data from seven new sites.

May 06, 2008

BP Dataset 12 Addition

P14K2b on Chromosome 4 / CERK, SULT4, BRD1, all genes on Chromosome 22

May 06, 2008

SZ Dataset 17 Addition

PLXNA2 Gene, 3 Microsatellite Markers and 4 SNPs Markers on Chromosome 1

April 11, 2008

CATIE Clinical Data

CATIE clinical data posted on Schizophrenia Dist. 5.0

April 02, 2008

BP Dataset 6-11 Additions

BP Dataset 6: 30 markers on 6 Chromosomes - trace amine receptors; BP Dataset 7: 62 SNPs on Chromosomes 3, 4, 11, 12, 18, 19, 22; BP Dataset 8: 19 SNPs on Chromosomes 1, 2, 11, 12, 17; BP Dataset 9: 93 SNPs on Chromosomes 1, 2, 4, 7, 8, 10, 11, 15, 17, 20; BP Dataset 10: 1004 SNPs on Chromosomes 1-13, 15-17, 19-23; BP Dataset 11: Pritzker 550K Illumina SNPs Phase 1

March 21, 2008

SZ Dataset 16 Addition

Syn2 Gene, 4 Microsatellite Markers and 11 SNPs Markers on Chromosome 3

March 20, 2008

CN Dataset 1

Raw .CEL files available for all samples genotyped using the Affymetrix GeneChip Human 500K Mapping Array Set

March 18, 2008

Schizophrenia Dist. 5.0

Schizophrenia Dist. 5.0 includes new data from Study 13 and Study 15

February 29, 2008

Autism Dataset 3 Addition

GWAS data on 1,264 non-AGRE samples

February 25, 2008

Bipolar Disorder Dist. 4.02

Bipolar Disorder Dist. 4.02 includes one new artificial record added to make a family pedigree drawing possible.

February 13, 2008

Bipolar Disorder Dist. 4.01

Bipolar Disorder Dist. 4.01 omits 8 records due to IRB issues.

February 13, 2008

Controls Dist. 6.11

Controls Dist. 6.11 includes corrections to sex for 4 subjects, omits 7 subjects due to unresolved discrepancies in reported sex vs. genotyped sex, omits 2 records for which DNA was unavailable, and omits 47 duplicate records.

February 01, 2008

Controls Dist. 6.1

Controls Dist. 6.1 omits 22 records that were included in Dist. 6.0, but had a Did Not Grow status from blood records.

December 03, 2007

SZ Dataset 15 Addition

21 Markers on Chromosome 4 and 43 Markers on Chromosome 22

November 13, 2007

CN Dataset 2 (Illumina SNPs)

Controls Dataset 2 updated with new file from Illumina

October 30, 2007

CN Dataset 2 (Illumina SNPs)

Data file for Controls Dataset 2 reissued

October 01, 2007

Controls Dist. 6.0

Controls Dist. 6.0 includes a total of 5212 cases. Phenotyping screening data is available for 4664 of these records.

September 14, 2007

SZ Dataset 14 Addition

5 BDNF SNPs Markers

September 14, 2007

SZ Dataset 12 Addition

Addition of 15 Markers on Chromosome X

September 01, 2007

Schizophrenia Dist. 4.0

Schizophrenia Dist. 4.0 includes new data from CATIE and Genome-Wide Association

August 21, 2007

Control Questionnaire access

Control Questionnaire no longer password protected

August 03, 2007

Schizophrenia Dist. 3.0

Genome linkage screen now available for Taiwan data

July 31, 2007

Bipolar Disorder Dist. 4.0

Bipolar Disorder Dist. 4.0 includes new data from an additional site that includes 281 records of newly identified independent cases and parent records from previous distribution versions 1.0 to 3.05.