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Bipolar Disorder

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Bipolar Disorder 12.3

The Bipolar Disorder (BP) Distribution v12.3 was published on 2021-11-10. There are 26286 subjects, 19586 of whom have at least one biospecimen on record at the repository. In addition to case/control studies, the BP collection includes 10 family studies, one or more of which include families that are large and/or multigenerational.

Standard Data & Documentation

  • Distribution Bundle [ or ]: Standard files across disorders, containing demographic, diagnostic, and pedigree information. Sampled (formerly IBX) sample IDs (nrgr_bio_id) and consent level are also provided. Bundle includes data dictionaries.
  • Study Descriptions.
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Additional Data Files

Genetic Data

Full Genome Genotyping

Genetic Data

Full Genome Genotyping

Clinical Instruments

DIGS

Diagnostic Interview for Genetic Studies (DIGS) - The CSV-format DIGS interview files provided below are cleaned versions of those received from the original study investigators. While they retain the record layouts and variable naming of their respective DIGS versions, they have had invalid values corrected or removed, date fields converted to a standard format, and their various missing/ unknown values converted to standard textual metavalues in order to avoid misinterpretation. Further details on the cleaning that has been performed are included in the file "bp-digs-cleaning-readme.txt" included in the download. To download the original files as received from study investigators, use "original" links below.

File B: This file includes DIGS info for all other sites in BP distribution 4.0. Data may be in DIGS version 1.0 or 2.0, but both versions have a core of variables in common.

Genetic Data

Targeted Genotyping

  • Trace amine-associated receptor genes association study (TRAR), 36 markers. 1,476 subjects.
  • Clock and circadian rhythm genes association study, 2 sets. 1,432 subjects in set 1, 1,243 subjects in set 2.
  • PDLIM5 family-based association study. 5 markers, 1,938 subjects.

Genetic Data

Targeted Genotyping

  • genotypes from Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus. 1,244 subjects.

Genetic Data

Full Genome Genotyping

  • Custom Illumina iSelect chip containing 7,584 SNPs on Chromosomes 1-22, 214 subjects.

Genetic Data

Targeted Genotyping

Genetic Data

Full Genome Genotyping

  • STEP-BD data. Case-control. 2453 samples (955 cases). PLINK files available from Affymetrix 5.0 platform. Study 29 controls included in dataset.
  • 720 markers on chromosomes 1-23. Controls from study 29. 832 subjects.

Genetic Data

Full Genome Genotyping

  • Case-Control data on 1956 samples. PLINK, logR/BAF files from Illumina 550k platform available. Intensity files are shipped by request due to the large size of the files. To request shipment, please contact help@nrgr.on.spiceworks.com and reference your active access approval ID.

Genetic Data

Full Genome Genotyping

  • Full Genome Screen. 624 markers, 238 subjects in 48 families
  • Full Genome Screen. 4,332 subjects.

Targeted Genotyping

  • 36 markers (4 on chromosome 13, 4 on chromosome 18, 3 on chromosome 21, 15 on chromosome 22, 6 on chromosome 4, and 4 on chromosome 5). 355 subjects.
  • Chromosome 5q31-34 / psychosis, GRIA1, 330 subjects.
  • 240 markers on Chromosomes 1-6, 8-13, 22, X, Y. 427 subjects.
  • 20 ANK3 markers on chromosomes 1-7, 10-13, 17. 2,519 subjects.
  • 10 Markers on Chromosome 22. 487 subjects.
  • 19 Cholinergic genes (93 SNPs) on 707 subjects. Includes family data
  • 1,005 neurotransmitter markers (GRIA1, GRIN2D, QDPR, GRIN2C, QDPR, slc6a3). 1,195 subjects.
  • K274E Mutation in PAH, 11 subjects.
  • 233 markers on Chromosomes 6, 12, 13, 18, 22. 2,127 subjects.
  • 62 SNPs on Chromosomes 3, 4, 11, 12, 18, 19, 22 - circadian rhythm pathways. 832 subjects.
  • 19 SNPs on Chromosomes 1, 2, 11, 12, 17 - circadian rhythm pathways. 1,435 subjects.
  • 93 SNPs on Chromosomes 1, 2, 4, 7, 8, 10, 11, 15, 17, 20 - cholinergic pathways. 401 subjects.
Clinical Instruments

BEFD

Genetic Data

Targeted Genotyping

  • 1004 SNPs on Chromosomes 1-13, 15-17, 19-23 family-based association study of neurotransmitter pathways, 735 subjects.
  • 30 trace amine receptors markers, 987 subjects
Clinical Instruments

BEFD

DIGS

Diagnostic Interview for Genetic Studies (DIGS) - The CSV-format DIGS interview files provided below are cleaned versions of those received from the original study investigators. While they retain the record layouts and variable naming of their respective DIGS versions, they have had invalid values corrected or removed, date fields converted to a standard format, and their various missing/ unknown values converted to standard textual metavalues in order to avoid misinterpretation. Further details on the cleaning that has been performed are included in the file "bp-digs-cleaning-readme.txt" included in the download. To download the original files as received from study investigators, use "original" links below.

File A: This file is in the DIGS version 3 paradox file format for distribution 4.01 data. It includes data for a group of 9 sites (from study1, wave3 & 4). These files are totally different in format from earlier versions (variable names, etc). This is DIGS 3.0/B.

Genetic Data

Targeted Genotyping

  • P14K2b on Chromosome 4 / CERK, SULT4, BRD1, all genes on Chromosome 22, 248 subjects
Clinical Instruments

BEFD

Clinical Instruments

BEFD

DIGS

Diagnostic Interview for Genetic Studies (DIGS) - The CSV-format DIGS interview files provided below are cleaned versions of those received from the original study investigators. While they retain the record layouts and variable naming of their respective DIGS versions, they have had invalid values corrected or removed, date fields converted to a standard format, and their various missing/ unknown values converted to standard textual metavalues in order to avoid misinterpretation. Further details on the cleaning that has been performed are included in the file "bp-digs-cleaning-readme.txt" included in the download. To download the original files as received from study investigators, use "original" links below.

File C: This file includes DIGS information for subjects in Study 8 added in BP Distribution 4.0. Data is in DIGS Version 2.0. Key variables are the same as in File B, but formats and variable lengths differ.

Clinical Instruments

BEFD

Clinical Trial

Other

Clinical Instruments

BEFD

DIGS

Diagnostic Interview for Genetic Studies (DIGS) - The CSV-format DIGS interview files provided below are cleaned versions of those received from the original study investigators. While they retain the record layouts and variable naming of their respective DIGS versions, they have had invalid values corrected or removed, date fields converted to a standard format, and their various missing/ unknown values converted to standard textual metavalues in order to avoid misinterpretation. Further details on the cleaning that has been performed are included in the file "bp-digs-cleaning-readme.txt" included in the download. To download the original files as received from study investigators, use "original" links below.

File D: This file includes DIGS information for subjects in Study 40 added in BP Distribution 6.02. This is a new version of DIGS.

Clinical Instruments

DIGS

Diagnostic Interview for Genetic Studies (DIGS) - The CSV-format DIGS interview files provided below are cleaned versions of those received from the original study investigators. While they retain the record layouts and variable naming of their respective DIGS versions, they have had invalid values corrected or removed, date fields converted to a standard format, and their various missing/ unknown values converted to standard textual metavalues in order to avoid misinterpretation. Further details on the cleaning that has been performed are included in the file "bp-digs-cleaning-readme.txt" included in the download. To download the original files as received from study investigators, use "original" links below.

DIGS data for Study 48 (Part 1)/Sites 186-188 (PIs: McMahon, DePaulo, Gershon) were collected using DIGS Version 3.0

Genetic Data

Full Genome Genotyping

  • SNP Linkage Genotyping Data, 5,606 markers, 2,466 subjects.
Clinical Instruments

DIGS

Diagnostic Interview for Genetic Studies (DIGS) - The CSV-format DIGS interview files provided below are cleaned versions of those received from the original study investigators. While they retain the record layouts and variable naming of their respective DIGS versions, they have had invalid values corrected or removed, date fields converted to a standard format, and their various missing/ unknown values converted to standard textual metavalues in order to avoid misinterpretation. Further details on the cleaning that has been performed are included in the file "bp-digs-cleaning-readme.txt" included in the download. To download the original files as received from study investigators, use "original" links below.

File E: This file includes DIGS information for subjects in Study 49 Version 2 added in BP Distribution 7.01. This is DIGS Version 2.0.

Clinical Instruments

Other

  • Interview data includes Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS), Children's Global Assessment Scale (C-GAS), Home Environment Interview for Children (HEIC)

Genetic Data

Full Genome Genotyping

Clinical Instruments

Other

  • Data includes MRI results, and Temperament Evaluation of Memphis, Pisa, Paris, and San Diego (TEMPS), Weschler Abbreviated Scale of Intelligence (WASI), California Verbal Learning Test (CVLT), among other interviews.

Clinical Instruments

Other

  • LiTMUS - primary outcome measures include Clinical Global Impression Scale for Bipolar Disorder Severity (CGI-BP-S) and medical adjustments per month. MINI-PLUS used to dermine DSM-IV diagnoses.

Clinical Instruments

DI-PAD

  • Diagnoses were reached using the OPCRIT system populated with DI-PAD data and supplemented by manual review of DI-PAD data as necessary.

Clinical Instruments

Clinical Trial

  • Diagnostic data, including Hamilton Depression Rating Scale, and response to Interpersonal and Social Rhythm therapy.

This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.

MULTIPLE — Studies BP0, 1

  • Trace amine-associated receptor genes association study (TRAR), 36 markers. 1,476 subjects.
  • Clock and circadian rhythm genes association study, 2 sets. 1,432 subjects in set 1, 1,243 subjects in set 2.
  • PDLIM5 family-based association study. 5 markers, 1,938 subjects.

MULTIPLE — Studies BP0, 1, 19

  • genotypes from Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus. 1,244 subjects.

MULTIPLE — Studies BP0, 1, 2

BP0 — NIMH BP Genetics Initiative

  • 36 markers (4 on chromosome 13, 4 on chromosome 18, 3 on chromosome 21, 15 on chromosome 22, 6 on chromosome 4, and 4 on chromosome 5). 355 subjects.
  • Chromosome 5q31-34 / psychosis, GRIA1, 330 subjects.
  • 240 markers on Chromosomes 1-6, 8-13, 22, X, Y. 427 subjects.
  • 20 ANK3 markers on chromosomes 1-7, 10-13, 17. 2,519 subjects.
  • 10 Markers on Chromosome 22. 487 subjects.
  • 19 Cholinergic genes (93 SNPs) on 707 subjects. Includes family data
  • 1,005 neurotransmitter markers (GRIA1, GRIN2D, QDPR, GRIN2C, QDPR, slc6a3). 1,195 subjects.
  • K274E Mutation in PAH, 11 subjects.
  • 233 markers on Chromosomes 6, 12, 13, 18, 22. 2,127 subjects.
  • 62 SNPs on Chromosomes 3, 4, 11, 12, 18, 19, 22 - circadian rhythm pathways. 832 subjects.
  • 19 SNPs on Chromosomes 1, 2, 11, 12, 17 - circadian rhythm pathways. 1,435 subjects.
  • 93 SNPs on Chromosomes 1, 2, 4, 7, 8, 10, 11, 15, 17, 20 - cholinergic pathways. 401 subjects.

Study 1 — A Collaborative Genomic Study of Bipolar Disorder

  • 1004 SNPs on Chromosomes 1-13, 15-17, 19-23 family-based association study of neurotransmitter pathways, 735 subjects.
  • 30 trace amine receptors markers, 987 subjects

Study 2 — Molecular Genetics of Bipolar Disorder

  • P14K2b on Chromosome 4 / CERK, SULT4, BRD1, all genes on Chromosome 22, 248 subjects

CAPS — Combined Analysis of Psychiatric Studies

PGC — Psychiatric GWAS Consortium

MULTIPLE — Studies BP0, 1, 40

  • Custom Illumina iSelect chip containing 7,584 SNPs on Chromosomes 1-22, 214 subjects.

MULTIPLE — Studies STEP-BD (19), MGS (29)

  • STEP-BD data. Case-control. 2453 samples (955 cases). PLINK files available from Affymetrix 5.0 platform. Study 29 controls included in dataset.
  • 720 markers on chromosomes 1-23. Controls from study 29. 832 subjects.

MULTIPLE — BP Dataset 11 (Pritzker)

  • Case-Control data on 1956 samples. PLINK, logR/BAF files from Illumina 550k platform available. Intensity files are shipped by request due to the large size of the files. To request shipment, please contact help@nrgr.on.spiceworks.com and reference your active access approval ID.

BP0 — NIMH BP Genetics Initiative

  • Full Genome Screen. 624 markers, 238 subjects in 48 families
  • Full Genome Screen. 4,332 subjects.

Study 49 — Genetics of Bipolar Disorder in Latino Populations

  • SNP Linkage Genotyping Data, 5,606 markers, 2,466 subjects.

Study 71 — Bipolar Endophenotypes in Population Isolates

BP0 — NIMH BP Genetics Initiative

Study 1 — A Collaborative Genomic Study of Bipolar Disorder

Study 2 — Molecular Genetics of Bipolar Disorder

Study 8 — Genetic Analysis of Bipolar Disorder

Study 19 — Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)

Study 40 — Bipolar Genome Study (BiGS)

Diagnostic Interview for Genetic Studies (DIGS) - The CSV-format DIGS interview files provided below are cleaned versions of those received from the original study investigators. While they retain the record layouts and variable naming of their respective DIGS versions, they have had invalid values corrected or removed, date fields converted to a standard format, and their various missing/ unknown values converted to standard textual metavalues in order to avoid misinterpretation. Further details on the cleaning that has been performed are included in the file "bp-digs-cleaning-readme.txt" included in the download. To download the original files as received from study investigators, use "original" links below.

MULTIPLE — Studies BP0, 2

File B: This file includes DIGS info for all other sites in BP distribution 4.0. Data may be in DIGS version 1.0 or 2.0, but both versions have a core of variables in common.

Study 1 — A Collaborative Genomic Study of Bipolar Disorder

File A: This file is in the DIGS version 3 paradox file format for distribution 4.01 data. It includes data for a group of 9 sites (from study1, wave3 & 4). These files are totally different in format from earlier versions (variable names, etc). This is DIGS 3.0/B.

Study 8 — Genetic Analysis of Bipolar Disorder

File C: This file includes DIGS information for subjects in Study 8 added in BP Distribution 4.0. Data is in DIGS Version 2.0. Key variables are the same as in File B, but formats and variable lengths differ.

Study 40 — Bipolar Genome Study (BiGS)

File D: This file includes DIGS information for subjects in Study 40 added in BP Distribution 6.02. This is a new version of DIGS.

Study 48 — Genetic Linkage and Association in Bipolar Disorder / Amish Mennonite Bipolar Genetics Study (AmBiGen)

DIGS data for Study 48 (Part 1)/Sites 186-188 (PIs: McMahon, DePaulo, Gershon) were collected using DIGS Version 3.0

Study 49 — Genetics of Bipolar Disorder in Latino Populations

File E: This file includes DIGS information for subjects in Study 49 Version 2 added in BP Distribution 7.01. This is DIGS Version 2.0.

Study 19 — Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)

Study 123 — Acute Psychotherapy for Bipolar II Depression

  • Diagnostic data, including Hamilton Depression Rating Scale, and response to Interpersonal and Social Rhythm therapy.

Study 19 — Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)

Study 55 — Adolescents at High Risk for Familial Bipolar Disorder

  • Interview data includes Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS), Children's Global Assessment Scale (C-GAS), Home Environment Interview for Children (HEIC)

Study 71 — Bipolar Endophenotypes in Population Isolates

  • Data includes MRI results, and Temperament Evaluation of Memphis, Pisa, Paris, and San Diego (TEMPS), Weschler Abbreviated Scale of Intelligence (WASI), California Verbal Learning Test (CVLT), among other interviews.

Study 75 — Lithium Use for Bipolar Disorder: A Randomized Controlled Effectiveness Trial (LiTMUS)

  • LiTMUS - primary outcome measures include Clinical Global Impression Scale for Bipolar Disorder Severity (CGI-BP-S) and medical adjustments per month. MINI-PLUS used to dermine DSM-IV diagnoses.

Study 77 — International Cohort Collection for Bipolar Disorder (ICCBD)

  • Diagnoses were reached using the OPCRIT system populated with DI-PAD data and supplemented by manual review of DI-PAD data as necessary.