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Psychiatric Genomics Consortium Bipolar Datasets

The Psychiatric Genomics Consortium (PGC) sent their full sample bipolar GWAS results, individual quality controlled genotypes, and individual level dosage data (from an imputation model) for a subset of the full sample (i.e., "deposited data") to the NIMH Repository for distribution to qualified investigators. The PGC was founded in 2007 to conduct meta-analyses of genome wide data on psychiatric disorders. A major goal of the PGC is sharing data with the international scientific community. More information on the PGC may be found at their website (https://www.med.unc.edu/pgc).

PGC Bipolar Datasets

The PGC sent summary statistics for the full BP sample, n=16731. In addition, subject-level data (original and imputed dosage genotypes) is provided for a subset of n=7,272 individuals, which excludes four samples (studies) due to restrictions on data sharing (see Table). The dosage genotype data is the result of an imputation model where fully observed snps are coded 0, 1, 2 and imputed snps have a single dosage on the interval [0,2]. The studies in the PGC that also have blood samples and/or phenotype data in the NIMH Repository are the GAIN and STEP-BD studies for BP cases, and the Gejman MGS controls for BP controls. Files available for download by authorized users include plots (Manhattan and QQ), a list of the top 1,000 SNPs, PLINK files of genotype data for individual datasets, and imputed dosage data for 2.4 M SNPs.

Sample Ancestry Cases Controls Platform
BOMA-Bipolar Study, University of Bonn and CIMH Mannheim German 675 1,297 Not distributed through NIMH
Genetic Association Information Network (GAIN) / Bipolar Genome Study (BiGS) European-American 542 649 Not distributed through NIMH
GlaxoSmithKline (GSK) British, Canadian or Scottish 890 902 Not publicly available
Pritzker Neuropsychiatric Disorders Research Consortium European-American 1,130 718 Illumina 550K
Systematic Treatment Enhancement Program for Bipolar Disorder (STEP1) European-American 922 645 Affymetrix 500K
Systematic Treatment Enhancement Program for Bipolar Disorder (STEP2) European-American 659 192 Affymetrix 5.0
Thematically Organized Psychosis (TOP) Study Norwegian 203 349 Affymetrix 6.0
Trinity College Dublin Irish 150 797 Affymetrix 6.0
University College London (UCL) British 457 495 Affymetrix 500K
University of Edinburgh Scottish 282 275 Affymetrix 6.0
Wellcome Trust Case-Control Consortium (WTCCC) British 1,571 2,931 Available through WTCCC