Controls

NOTE: The distribution refers to a collection of studies organized by disorder or theme (see FAQ).  It is important to note that not all individuals in the distribution have DNA available.

Given the major public health implications of identifying genes responsible for severe neuropsychiatric disorders, the National Institute of Mental Health (NIMH) has funded a Human Genetics Initiative. The goal of this Initiative is to establish a national resource of clinical data and biomaterials that are collected from individuals with autism, schizophrenia, bipolar I disorder, depression, obsessive-compulsive disorder, and other mental disorders. The NIMH Autism Genetics Initiative is supported by the Office of Human Genetics & Genomic Resources in NIMH's Division of Neuroscience and Basic Behavioral Science (DNBBS). Starting in 2001, data and biomaterials (cell lines and DNA samples) will be available to qualified investigators who study the genetics of autism, and may be accessed by following a set of instructions.

In order to enable case-control association studies, a set of controls are now available as part of the Human Genetics Initiative. The control sample consists of a group of all Caucasian individuals for whom cord blood was obtained, and a group of adults who completed an online, short self-report clinical assessment.

The consent for controls included authorization for qualified scientists, with approval from NIMH, to study any condition or trait.

List of Studies

Available for Download

Study Title Distributions PIs Grants Sites Target Sample Size GWAS Notes
Study 19 STEP-BD; Treatment of Bipolar Disorder Controls Sachs, Nimgaonkar N01MH080001 14, 78, 86, Site 88-Controls 2365

847 cases and 453 ctls in STEP-BD GWAS; 486 in NIMH Controls DS 1;  105 in dbGap NIMH-CTL Exome;

Study 23 Genetic Susceptibility in Schizophrenia Controls Nimgaonkar R01MH056242 73 489
Study 29 Molecular Genetics of Schizophrenia Controls Gejman, Levinson, Buccola, Mowry, Freedman, Amin, Byerley, Crowe, Silverman, Cloninger R01MH059571 139-150 8989

 

1212 in NIMH Controls DS 1
463 in NIMH DS 2
1705 in dbGaP BP GAIN
1033 in STEP-BD GWAS
461 in GWAS Pritzker 1
311 in GWAS Pritzker 2
2142 cases and 2332 ctls in dbGaP SZ GAIN
1141 cases and 1379 ctls in dbGaP SZ Non-GAIN
748 in NIMH SZ DS 13
848 in exome seq dbGap ARRA
946 in dbGap NIMH-CTL Exome

446 ctls and 352 cases  in dbGap jointGWinMGS

26 in SICCA NIMH CN 3

382 in SZ DS31_1

Study 76 Genomic Psychiatry Cohort (GPC) Controls Pato, Pato, Knowles, Marder, Rapaport, Perkins, Buckley, Morley, Bromet, Lehrer, Malaspina, Escamilla, Nicolini 3R01MH085548-03S1 251,262-269, 271, 351-352, 844 19657
Study 77 International Cohort Collection for Bipolar Disorder Controls Smoller, Sklar, Pato, Knowles, Bromet, Rapaport, Buckley, Escamilla, Morley, Dewan, Lehrer, Marder, Perkins, Malaspina, Nicolini R01MH085542 252, 270, 272-275, 304-312, 845 8947

In Progress*

Study Title Distributions PIs Grants Sites Target Sample Size GWAS Notes
Study 77 International Cohort Collection for Bipolar Disorder Controls Smoller, Sklar, Pato, Knowles, Bromet, Rapaport, Buckley, Escamilla, Morley, Dewan, Lehrer, Marder, Perkins, Malaspina, Nicolini R01MH085542 252, 270, 272-275, 304-312, 845 8947

*Studies in progress includes those available for download for which some future action is required

Rutgers University Rutgers University USC Information Sciences Institute Washington University in St.Louis National Institute of Mental Health