Diagnostic Interview for Psychosis and Affective Disorders

Updated for OPCRIT 4.0 DSM-IV & ICD 10 Algorithms)
DI-PAD (CGP Version 1.5)

Study 76 was supported by NIMH grant 3R01MH085548-03S1; Dr. Carlos Pato is the contact Principal Investigator.

General Hospital (MGH)-Broad Institute (Stanley Center) and a nation-wide network of academic medical centers have created the Genomic Psychiatry Cohort (GPC). The GPC is a large clinical cohort of patients with schizophrenia and controls who may be prospectively followed to allow ongoing assessment of phenotype. Most participants agreed to future contact which will facilitate the conduct of additional studies.

Control subjects were screened to exclude individuals with personal or family history of psychosis or mania. All cases were assessed by structured clinical interviews using the Diagnostic Interview for Psychosis and Depression (DI-PAD). Diagnoses were reached using the OPCRIT system populated with DI-PAD data and supplemented by manual review of DI-PAD data as necessary. Genotyping of subjects has been performed by the Broad Institute of MIT and Harvard, University of Michigan/HudsonAlpha Institute for Biotechnology, and USC.

Funding from the NIMH grant R01MH085548 to Carlos Pato and Michele Pato (Co-PIs) (USC) supported the collection of over 30,000 subjects at multiple collaborating sites. USC site investigators are Helena Medeiros, James Knowles and Janet L. Sobell; Emory University site investigators are Mark H. Rapaport (site PI) and Jeff Rakovsky; State University of New York at Stony Brook investigators are Eveline Bromet (site PI) and Laura Fochtmann; State University of New York, Upstate Medical University investigator is Christopher Morley; New York University investigator is Dolores Malaspina; Wright State University investigator is Douglas Lehrer; University of North Carolina site investigator is Diana Perkins; Georgia Regents University investigator is Peter Buckley; University of California, Los Angeles investigator is Stephen Marder; University of California, Irvine site investigators are Fabio Macciardi (site PI) and Marquis Vawter; Texas Tech University Health Sciences Center at El Paso investigator is Michael Escamilla; University of Coimbra, Portugal site investigator is Maria Azevedo; Carracci Medical Group, Mexico site investigator is Humberto Nicolini, and Veterans Administration Medical Center site investigator is Ayman Fanous. Other Genomic Psychiatry Cohort Consortium members are Brooke Sklar, Colony Abbott, Rute Ferreira, Becky L. Kinkead, and Nuria Lanzagorta.

Study 77 / International Cohort Collection for Bipolar Disorder

The International Cohort Collection for Bipolar Disorder (ICCBD) was formed to foster discoveries in the genetics of bipolar disorder by developing and applying high-throughput phenotyping methods, conducting genomewide association analyses, and providing tools for further discovery to the wider scientific community. The ICCBD comprises an international collaboration among investigators at U.S. and European sites and was designed to 1) collect phenotypic data and DNA samples from a large number of individuals with bipolar disorder (N=19,000) and unaffected controls (19,000); 2) construct a harmonized data resource for genetic studies; and 3) conduct genomic studies to characterize the genetic basis of bipolar disorder. Funding from the NIMH grant R01MH085542 to Jordan W. Smoller and Pamela Sklar supported the collection of 9,000 cases and 9,000 controls at two U.S. centers: Partners Healtcare/Massachusetts General Hospital, and the University of Southern California (Site PI: Carlos Pato). Rapid phenotyping methods were used at the U.S. sites including use of electronic health records (Partners) and focused direct interviews (USC). In parallel, data and samples for 9,000 cases were collected through Cardiff University (Site PI: Nick Craddock) and the Karolinska Institutet (Site PI: Mikael Landen) and funded by the Stanley Medical Research Institute.

Other investigators were Roy H. Perlis, Isaac S. Kohane, Phil Hyoun Lee, Victor M. Castro, Alison G. Hoffnagle (Massachusetts General Hospital), Eli A. Stahl, Shaun M. Purcell, Douglas M. Ruderfer, Alexander W. Charney, Panos Roussos (Icahn School of Medicine at Mount Sinai), Michele Pato, Helen Medeiros, Janet Sobell, James Knowles (University of Southern California), Ian Jones, Liz Forty, Arianna DiFlorio, Elaine Green (Cardiff University), Lisa Jones, Katherine Dunjewski (Birmingham University), Mikael Landen, Christina Hultman, Anders Juréus, Sarah Bergen, and Oscar Svantesson (Karolinska Institutet); and Steven McCarroll, Jennifer Moran, Jordan W. Smoller, Kimberly Chambert, Richard A. Belliveau, Jr. (Stanley Center for Psychiatric Research, Broad Institute).

Castro VM, Minnier J, Murphy SN, Kohane I, Churchill SE, Gainer V, Cai T, Hoffnagle AG, Dai Y, Block S, Weill SR, Nadal-Vicens M, Pollastri AR, Rosenquist JN, Goryachev S, Ongur D, Sklar P, Perlis RH, Smoller JW for the International Cohort Collection for Bipolar Disorder. Validation of Electronic Health Record Phenotyping of Bipolar Disorder Cases and Controls. Am J Psychiatry 2014 (ahead of print).

Hartz SM, Pato CN, Medeiros H, Cavazos-Rehg P, Sobell JL, Knowles JA, Bierut LJ, Pato MT; Genomic Psychiatry Cohort Consortium. Comorbidity of severe psychotic disorders with measures of substance use.  JAMA Psychiatry 2014 Mar; 71(3):248-254. PMCID: PMC4060740

Pato MT, Sobell JL, Medeiros H, Abbott C, Sklar BM, Buckley PF, Bromet EJ, Escamilla MA, Fanous AH, Lehrer DS, Macciardi F, Malaspina D, McCarroll SA, Marder SR, Moran J, Morley CP, Nicolini H, Perkins DO, Purcell SM, Rapaport MH, Sklar P, Smoller JW, Knowles JA; Genomic Psychiatry Cohort Consortium, Pato CN. The genomic psychiatry cohort: partners in discovery. Am J Med Genet B Neuropsychiatr Genet 2013 Jun; 162B(4):306-312. PMCID: PMC3729260

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