Netherlands Twin Register (NTR)

NOTE: The distribution refers to a collection of studies organized by disorder or theme (see FAQ).  It is important to note that not all individuals in the distribution have DNA available.

Given the major public health implications of identifying genes responsible for severe neuropsychiatric disorders, the National Institute of Mental Health (NIMH) has funded a Human Genetics Initiative. The goal of this Initiative is to establish a national resource of clinical data and biomaterials that are collected from individuals with autism, schizophrenia, bipolar I disorder, depression, obsessive-compulsive disorder, and other mental disorders.

Clinical data will be available soon.

The principal investigator is Dorret I. Boomsma, Ph.D., and the Netherlands Twin Register Collaborative Genetic study was funded by the following:

Funding was obtained from the Netherlands Organisation for Scientific Research (NWO):

  • Twin family database for behavior genomics studies (NWO 480-04-004);
  • NTR BioBank for large scale genetic epidemiological studies (NWO 91109032);
  • CMSB: Center for Medical Systems Biology (NWO Genomics);
  • Spinozapremie (SPI 56-464-14192)

And from:

  • VU University Faculty of Psychology and Education;
  • VU University Centre for Neurogenomics and Cognitive Research (CNCR);
  • European Science Foundation (ESF): Genomewide analyses of European twin and population cohorts (EU/QLRT-2001-01254);
  • A collaborative study of the genetics of DZ twinning (NIH R01D0042157-01A);
  • Rutgers University Cell and DNA Repository cooperative agreement (NIMH U24 MH068457-06)

Investigators and co-investigators are: VU University Amsterdam: Dorret I. Boomsma, Eco JC de Geus, Gonneke Willemsen, Jouke-Jan Hottenga. Jacqueline Vink, August B. Smit; VU Medical Center, Amsterdam: Brenda Penninx, Jan Smit, Patrizia Rizzu; Rutgers University (USA): Andy I. Brooks, Douglas A. Fugman, Jay A. Tischfield; Good Biomarker Sciences, Leiden: Kees Kluft, Piet Meijer; Queensland Institute of Medical Research (Australia): Grant W. Montgomery; Leiden University Medical Centre: H. Eka D. Suchiman, P. Eline Slagboom.

Description: In 1987, the Netherlands Twin Register was established (NTR; Boomsma et al. 2006) as a resource for prospective studies in behavior genetics and genetic epidemiology (please see www.tweelingenregister.org). The register now includes over 22,000 active adult participants who take part in research projects (in addition, newborn twins are recruited at birth and followed throughout life).

Data and biomaterials (cell lines and DNA samples) are available to qualified investigators who study the genetics of obsessive-compulsive disorder, and may be accessed by following a set of instructions.

List of Studies

Available for Download

Study Title Distributions PIs Grants Sites Target Sample Size GWAS Notes
Study 78 Netherlands Twin Register Netherlands Twin Register Boomsma, de Geus R01D0042157-01A 169 8540

In Progress*

No studies found.

Rutgers University Rutgers University USC Information Sciences Institute Washington University in St.Louis National Institute of Mental Health