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Induced Pluripotent Stem Cells
Induced Pluripotent Stem Cells 11.3
The Induced Pluripotent Stem Cell (iPSC) Distribution v11.3 was published on 2023-10-01. There are 819 subjects, 804 of whom have at least one biospecimen on record at the repository. There are 472 iPSCs, 568 FCLs, and 8 OEs as of the date of release. In addition to case/control studies, the iPSC collection includes 8 family studies. The most recent update adds the following study: Study 182 (PIs: Duan, Penzes; R01MH106575, R21MH102685) includes 21 individuals, 21 of whom have at least one biospecimen on record at the repository. There are 51 iPSCs.
Standard Data & Documentation
Download All- Distribution Bundle [text or excel]: Standard files across disorders, containing demographic, diagnostic, and pedigree information. Sampled (formerly IBX) sample IDs (nrgr_bio_id) and consent level are also provided. Bundle includes data dictionaries.
- Study Descriptions.
- Change Notes.
- Pedigree Drawings.
Additional Data Files
This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.
Clinical Instruments
iPSC Submitter Form
- Study 115 Singec iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.
Other
This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.
Study 127
Target Identification and Validation for Negative Symptoms and Social Cognition in Schizophrenia: A Translational Study
8
This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.
This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.
This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.
Study 132
NIMH DIRP Protocol 03-M-0035 Screening, Evaluation, Diagnosis, Treatment Optimization and Follow-Up for Childhood Onset Psychiatric Disorders
228
This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.
This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.
This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.
This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.
This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.
This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.
This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.
This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.
This study does not have any additional genetic or clinical data. All study data is included in the standard distribution files above.
Clinical Instruments
iPSC Submitter Form
- Study 182 iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.
Study 115 — Exploring the Neuronal Phenotype of Autism Spectrum Disorders Using iPSCs
- Study 115 Singec iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.
Study 182 — Systematic Functional Interpretation of Regulatory Variants in Schizophrenia
- Study 182 iPSC Submitter Form [text or excel] The iPSC Submitter Form contains one row per iPSC line received, and records the provenance of the cell line (source/parental cell line IDs), genetic diagnosis and/or modifications, passage number, cell growth conditions and reprogramming conditions at the time of cell line submission. For final conditions after successful regrowth and banking at IBX, see the Certificate of Analysis.
Study 115 — Exploring the Neuronal Phenotype of Autism Spectrum Disorders Using iPSCs
- Phenotypic Data [text or excel] Includes demographics, diagnoses, body measurements, brain scan data, and summary data from ADI-R, ADOS, Mullen, SRS instruments. Additional subjects for study 115 can be found in the Phelan-McDermid Syndrome (PMS) collection.
Study 116 — Cellular and genetic correlates of increased head size in autism spectrum disorder
- Phenotypic Data [text or excel] Includes item-level data for ADI, ADOS, DAS, Mullen, Vineland, and WISC instruments, along with NDA linking IDs.
Study 117 — Autism iPSCs for Studying Function and Dysfunction in Human Neural Development
- Phenotypic Data [text or excel] Includes demographics, diagnosis, and summary data from ADI, ADOS, and Stanford-Binet
Study 158 — Modeling schizophrenia using iPSC neurons
Study 166 — Juvenile Onset Schizophrenia iPSCs
- Study 166 Phenotypic Data [text or excel] s166-misc-phen (n=8) includes medications at time of biopsy and Children’s Global Assessment Score.
Study 200 — Mechanisms of Circuit Failure and Treatments in Patient-derived Neurons in Autism