NRGR - Data Submission

NIMH-funded studies are required to submit data to the NRGR, based upon the terms described in their Notice of Grant Award and Data Sharing Plans. The NRGR collects, curates, and distributes collected data via a combination of automated Quality Control and human curation to ensure data is submitted in accordance with study-specific requirements.

To get access to the QC system and/or when you are ready to submit data, contact pheno_qc@nimhgenetics.org for guidance. You will be put in contact with an expert human curator who specializes in your disorder. They will walk you through the process of submitting data through the auto QC system, and help to answer any specific questions you may have.

Overview

Submission Format

Data submitted to the center must be formatted in accordance with the Auto-QC System’s requirements. Detailed descriptions and sample files can be found on the QC Help Page.

Overview

The Auto-QC system takes in a .zip package of required files. Files are checked for agreement with defined data dictionaries, as well as higher-level checks. These include pedigree checks (are mothers female? Are children younger than parents?), cross-database checks (are RUID’s and PARTID’s accurate according to RUCDR records?), and diagnosis checks (are submitted diagnoses compatible?). Although the error-checking is automated, the Auto-QC system does not automatically correct errors. The investigator must review error logs generated by the QC System, make the necessary changes, and re-submit a corrected .zip package to the system.

Next Steps?

After all files pass successfully through the Auto-QC system, the investigator has the option to submit the successful package to expert curators at Washington University – St. Louis. The expert curators review the submission to ensure that data submitted matches the expected data based on the study’s Notice of Grant Award and Data Sharing Plan. If any additional updates to the submission are required, the curator will reach out to the submitting study. If the data submitted is clean and in accordance with NIMH requirements, the data will be included in the next distribution released by NRGR.

The Auto-QC system can also be used for internal QC. Upon successful completion of Auto QC, the investigator can decide not to send the file on for manual curation. This way, the QC system can be used to ensure file formats are correct and data is clean well ahead of their required submission date.

To get access to the QC system and/or when you are ready to submit data, contact pheno_qc@nimhgenetics.org for guidance. You will be put in contact with an expert human curator who specializes in your disorder. They will walk you through the process of submitting data through the auto QC system, and help to answer any specific questions you may have.