Schizophrenia

NOTE: The distribution refers to a collection of studies organized by disorder or theme (see FAQ).  It is important to note that not all individuals in the distribution have DNA available.

Given the major public health implications of identifying genes responsible for severe neuropsychiatric disorders, the National Institute of Mental Health (NIMH) has funded a Human Genetics Initiative. The goal of this Initiative is to establish a national resource of clinical data and biomaterials that are collected from individuals with Alzheimer disease, schizophrenia (SZ), or bipolar I disorder, in order to aid researchers in understanding the genetic bases of these disorders. The NIMH Schizophrenia Genetics Initiative is supported by the Office of Human Genetics & Genomic Resources in NIMH's Division of Neuroscience and Basic Behavioral Science (DNBBS). Since 1996 data and biomaterials (cell lines and DNA samples) have been available to qualified investigators who study the genetics of SZ, and may be accessed by following a set of instructions.

From 1991-98, SZ pedigrees were ascertained by three extramural sites (Columbia University, Harvard University, and Washington University). In 1998, NIMH issued a Request for Applications (MH-98-010) to solicit applications for collaborative research projects to collect large pedigree samples and conduct molecular genetic analyses on schizophrenia, bipolar disorder, and early-onset recurrent unipolar depression. Another solicitation (MH-99-005) was issued in 1998 that focused on schizophrenia and early-onset recurrent depression. Data and biomaterials collected and produced in these projects will augment existing resources in the NIMH SZ Genetics Initiative that are distributed to the scientific community.

One award was made under MH-98-010 to Harvard University, and SZ pedigree collection is supported at two international sites (National Taiwan University Hospital in Taipei, Taiwan and Sun Yat-Sen University of Medical Sciences in Guangzhou, People's Republic of China). Establishment of DSM-III-R and DSM-IV diagnoses is made following a systematic and comprehensive examination of multiple sources of available information obtained from relatives, medical records, and direct assessment using the Diagnostic Interview for Genetic Studies (DIGS). Nuclear and extended pedigrees have been ascertained in which there are at least two individuals affected with SZ who are first-degree biological relatives.

Anonymous data in the NIMH SZ Genetics Initiative on family structure, age, sex, vital status, psychopathology, diagnosis, and other clinically relevant information, as well as lymphoblastoid cell lines and DNA, are stored, maintained and distributed by the NIMH Center for Genetic Studies. The Center is operated under an NIMH contract to Washington University and subcontract to Rutgers University.

Study 59: SZ version 10.0 was appended to include data from this study. Study 59 was funded through the NIMH grant R01 MH078075 entitled "High-density Genome-wide Association Study Schizophrenia". Principal investigator was Roel A. Ophoff, Ph.D., UCLA. The goal of this project was to perform a genome-wide association study in a schizophrenia cohort from The Netherlands.

List of Studies

Available for Download

Study Title Distributions PIs Grants Sites Target Sample Size GWAS Notes
SZ 0 Linkage Studies of Schizophrenia Schizophrenia Tsuang, Cloninger, Kaufmann 5U01MH046318, 5U01MH046276, 5U01MH046289 30-32 877

35 in dbGaP SZ GAIN;73 in dbGap SZ non-GAIN;

Study 3 Genetic Linkage Study of Schizophrenia Schizophrenia Tsuang M R01MH059624 Site 34-China; Site 35-Taiwan 2328
Study 6 Molecular Genetics of Schizophrenia Schizophrenia Gejman, Murphy, Mowry, Freedman, Amin, Byerley, Black, Silverman, Levinson, Cloninger R01MH059571 40-49 1383

275 in dbGaP GAIN; 196 in dbGaP Non-GAIN;29 in dbGap jointGWinMGS;

Study 9 A study of Schizophrenia Schizophrenia Weinberger (original PI: Egan) 39
Study 12 Genetic Analysis of Psychosis Schizophrenia Pato R01MH052618 33 233
Study 13 Genetics of Schizophrenia in Latino Populations Schizophrenia Escamilla, Raventos, Munoz, Ontiveros, Nicolini, Mendoza, Jerez, Canive R01MH060881 17, 53-59 1241
Study 15 A Neurobehavioral Family Study of Schizophrenia Schizophrenia Gur, Nimgaonkar R01MH042191 70-71 645
Study 17 CATIE; Replication of Schizophrenia Associations in CATIE Schizophrenia Lieberman, Sullivan N01MH090001, R01MH074027 Site 75-AD; Site 76-SZ 741

741 in NIMH SZ DS 13 (CATIE);291 in NIMH SZ 27;

Study 22 PAARTNERS; Schizophrenia Liability Genes Among African Americans Schizophrenia Go, Nimgaonkar, Kwentus, Edwards, McEvoy, Bradford, Santos, Devlin R01MH066181 101-109 1739

12 in dbGap Exome seq in SZ fam;

Study 23 Genetic Susceptibility in Schizophrenia Schizophrenia Nimgaonkar R01MH056242 73 489
Study 27 The Genetics of Endophenotypes and Schizophrenia Schizophrenia Braff, Freedman, Tsuang M., Green, Siever, Gur, Tsuang D. R01MH065571 122-128 (COGS 1), 253-257 (COGS 2) 2000

202 in dbGap Exome seq in SZ fam;

1 in dbGaP SZ-Gain; 1 in dbGaP SZ-non-Gain;

Study 29 Molecular Genetics of Schizophrenia Schizophrenia Gejman, Levinson, Buccola, Mowry, Freedman, Amin, Byerley, Crowe, Silverman, Cloninger R01MH059571 139-150 8989

 

1212 in NIMH Controls DS 1
463 in NIMH DS 2
1705 in dbGaP BP GAIN
1033 in STEP-BD GWAS
461 in GWAS Pritzker 1
311 in GWAS Pritzker 2
2142 cases and 2332 ctls in dbGaP SZ GAIN
1141 cases and 1379 ctls in dbGaP SZ Non-GAIN
748 in NIMH SZ DS 13
848 in exome seq dbGap ARRA
946 in dbGap NIMH-CTL Exome

446 ctls and 352 cases  in dbGap jointGWinMGS

26 in SICCA NIMH CN 3

382 in SZ DS31_1

Study 42 A Genome Wide SNP Association Study: Schizophrenia Schizophrenia Pulver R01MH068406 185 197
Study 59 High-Density Genome-Wide Association Study of Schizophrenia in Large Dutch Sample Schizophrenia Ophoff R01MH078075 100 331
Study 67 Population Based Mapping of Schizophrenia Genes Schizophrenia Escamilla, Raventos R01MH061884 129 1500
Study 68 Biological Prediction of Psychosis Susceptibility among Adolescent Cannabis Users Schizophrenia DeLisi R01DA021576 18, 131 320
Study 72 Prediction of Relapse in Schizophrenia Schizophrenia Miller, Buckley, Goff, Lauriello, Manschreck, Mendelowitz, Wilson, Kopelowicz 3U01MH070010 261 230
Study 76 Genomic Psychiatry Cohort (GPC) Schizophrenia Pato, Pato, Knowles, Marder, Rapaport, Perkins, Buckley, Morley, Bromet, Lehrer, Malaspina, Escamilla, Nicolini 3R01MH085548-03S1 251,262-269, 271, 351-352, 844 19657
Study 82 Expanding Rapid Ascertainment Networks of Schizophrenia Families in Taiwan Schizophrenia Tsuang M., Hwu R01MH085560 183 12000
Study 85 Language and Risk in Schizophrenia Schizophrenia DeLisi R21MH083205 260 90
Study 90 A genome-wide association study of Schizophrenia in Ireland Schizophrenia Riley, Corvin, O'Neill R01MH083094 301-302 1500

Received GWAS data on portable hard drive on 7-22-2015

Study 91 Whole-genome sequencing for rare highly penetrant gene variants in schizophrenia Schizophrenia Goldstein RC2MH089915 258-259 110

162 in dbGaP phs000682

 

Study 92 Family-Based Genome-Wide Methylation Scan in Neurocognition and Schizophrenia Schizophrenia Gur, Nimgaonkar RC2MH089973, RC2MH089859 320-323 200
Study 94 Common and rare variant genetic screens for clozopine-induced agranulocytosis (CIAC) Schizophrenia Sullivan, Lieberman, Malhotra, Kennedy R01MH080403 324-326 1000

22 in SZ DS31_1; 282 in SZ DS31_2;282 in SZ DS31_3;

Study 104 Comparison of Long-Acting Injectable Medications for Schizophrenia (ACLAIMS) Schizophrenia Stroup, Lawrence, Byerly, Caroff, D'Souza, Khan, Lamberti, Lieberman, McEvoy, Miller, Steinbook, Jarskog, Buckley, Desouza, D'Mello, Grabowski, Hicks, Hoblyn, Konicki, Tran, Wilson, Millet R01MH081107 327-347 360
Study 122 Characterization of a Mendelian Form of Psychosis in a Population Isolate Schizophrenia Raventos, Glahn, Almasy R56MH097940 319 200
Study 158 Modeling schizophrenia using iPSC neurons Schizophrenia Brennand, Gage Supported by private funds 361 14

In Progress*

Study Title Distributions PIs Grants Sites Target Sample Size GWAS Notes
Study 9 A study of Schizophrenia Schizophrenia Weinberger (original PI: Egan) 39
Study 15 A Neurobehavioral Family Study of Schizophrenia Schizophrenia Gur, Nimgaonkar R01MH042191 70-71 645
Study 27 The Genetics of Endophenotypes and Schizophrenia Schizophrenia Braff, Freedman, Tsuang M., Green, Siever, Gur, Tsuang D. R01MH065571 122-128 (COGS 1), 253-257 (COGS 2) 2000

202 in dbGap Exome seq in SZ fam;

1 in dbGaP SZ-Gain; 1 in dbGaP SZ-non-Gain;

Study 107 RAISE - Early Treatment Program (ETP) Genetics Schizophrenia Kane, et al. HHSN-271-2009-00019C 350 (all 32 sites using site # 350; have subsite #s) 400
Study 150 A Study of Schizophrenia Schizophrenia Sullivan, Farrell, Josiassen, Shaughnessy, Evans There is no grant number associated with this study 354 1000
Study 156 Transferred from Coriell Collection Schizophrenia DeLisi, Gershon Site 735 (BP); Site 736 (SZ) 2500

*Studies in progress includes those available for download for which some future action is required

Rutgers University Rutgers University USC Information Sciences Institute Washington University in St.Louis National Institute of Mental Health