PsychENCODE Consortium Data
The PsychENCODE Consortium (http://www.synapse.org/pec) has a collective goal of accelerating discovery of non-coding functional genomic elements in human brain, and elucidating their role in the molecular pathophysiology of psychiatric disorders. The PEC is producing a public resource of multi-dimensional genomic data using unbiased genome-wide approaches on tissue and cell-type specific samples from approximately 1000 phenotypically well-characterized healthy and diseased human post-mortem brains. The PEC also shares data from functional characterization of disease-associated regulatory elements and variants in in-vitro and in-vivo model systems.
The PsychENCODE investigators are committed to the release of data and results with the anticipation that data shared in a rapid and transparent manner will speed the pace of research to the benefit of both the PsychENCODE teams and the greater research community.
Funding through the following NIH grants has supported data generation: U01MH103339, U01MH103365, U01MH103392, U01MH103340, U01MH103346, R01MH105472, R01MH094714, R01MH105898, R21MH102791, R21MH105881, R21MH103877, and P50MH106934 awarded to: Schahram Akbarian (Icahn School of Medicine at Mount Sinai), Gregory Crawford (Duke), Stella Dracheva (Icahn School of Medicine at Mount Sinai), Peggy Farnham (USC), Mark Gerstein (Yale), Daniel Geschwind (UCLA), Thomas M. Hyde (LIBD), Andrew Jaffe (LIBD), James A. Knowles (USC), Chunyu Liu (UIC), Dalila Pinto (Icahn School of Medicine at Mount Sinai), Nenad Sestan (Yale), Pamela Sklar (Icahn School of Medicine at Mount Sinai), Matthew State (UCSF), Patrick Sullivan (UNC), Flora Vaccarino (Yale), Sherman Weissman (Yale), Kevin White (UChicago) and Peter Zandi (JHU).
The PsychENCODE Consortium data consists of a set of human studies controlled through this distribution, and animal models provided as open access. All data is distributed through the Sage Bionetworks Synapse system (http://www.synapse.org/pec). To download the human data, applicants must obtain a Synapse data access token before submitting an application to NIMH RGR. See instructions of how to obtain the token and how to proceed with the NIMH data access application here.
Applicants will then request access to the PsychENCODE Consortium data following the NIMH RGR instructions for access. The applicant's Synapse token must be included with the NIMH RGR submission package along with the other required documents.