Induced Pluripotent Stem Cells (iPSC)

NOTE: The distribution refers to a collection of studies organized by disorder or theme (see FAQ).  It is important to note that not all individuals in the distribution have DNA available.

The National Institute of Mental Health (NIMH) Center for Collaborative Studies of Mental Disorders has established cell lines and DNA for this initiative since 1998. The NIMH collection now contains a vast array of samples from families with schizophrenia, bipolar disorder, Alzheimer's disease, autism, obsessive-compulsive disorder, depression, and ADHD. Many important discoveries have been made by investigators accessing these collections. There is a catalog listing cells available under the NIMH program.

The Center for Collaborative Genomic Studies on Mental Disorders is a collaboration of Rutgers University RUCDR, Washington University in St. Louis, and the University of Southern California's Information Sciences Institute. It is funded by a grant from the National Institute Mental Health.

The purpose of the NIMH Stem Cell Center is to provide a resource for postnatal-to-adult human control and patient-derived cells and their reprogrammed derivatives; this repository will support stem cell research relevant to mental disorders. This includes but is not limited to anxiety disorders, attention deficit hyperactivity disorder, autism spectrum disorders, bipolar diorder, borderline personality disorder, depression, eating disorders, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, and schizophrenia. The capabilities of the repository will range from derivation and banking of primary source cells from postnatal through adult human subject tissue to more comprehensive banking and validation of iPSCs or similar reprogrammed/de-differentiated cells.

Data and biomaterials (cell lines and DNA samples) are available to qualified investigators and may be accessed by following a set of instructions.

List of Studies

Available for Download

Study Title Distributions PIs Grants Sites Target Sample Size GWAS Notes
Study 92 Family-Based Genome-Wide Methylation Scan in Neurocognition and Schizophrenia iPSC Gur, Nimgaonkar RC2MH089973, RC2MH089859 320-323 200
Study 115 Exploring the Neuronal Phenotype of Autism Spectrum Disorders Using Induced Pluri iPSC Hallmayer, Dolmetsch R33MH087898 726 & 734 150
Study 116 Cellular and genetic correlates of increased head size in autism spectrum disorder iPSC Vaccarino R33MH087879 727 40
Study 117 Autism iPSCs for Studying Function and Dysfunction in Human Neural Development iPSC Loring R33MH087925 728 8
Study 125 Analysis of Glutamatergic Neurons Derived from Patient Specific iPS Cells iPSC Lachman, Rapoport R33MH087840 392-393 31
Study 127 Target Identification and Validation for Negative Symptoms and Social Cognition in Schizophrenia: A Translational Study iPSC Hahn Target Identification and Validation for Negative Symptoms and Social Cognition in Schizophrenia: A Translational Study 717 50
Study 130 Genomics-Guided Characterization of iPS Cells from Common Mental Illnesses iPSC Haggarty, Perlis R21MH093958, R33MH087896 433-434 27
Study 131 Chemical genomic approaches to neurobiology of DISC1 iPSC Tsai, Perlis, Cohen R01MH091115 317-318 40
Study 132 NIMH DIRP Protocol 03-M-0035 Screening, Evaluation, Diagnosis, Treatment Optimization and Follow-Up for Childhood Onset Psychiatric Disorders iPSC Rapoport 1ZIAMH002581 499, 502 270
Study 143 Modeling Anorexia Nervosa with Human Pluripotent Stem Cells iPSC Muotri R21MH093954-02 408 30
Study 144 Modeling Autism with Human Pluripotent Cells iPSC Muotri 1DP2OD006495 738 81
Study 158 Modeling schizophrenia using iPSC neurons iPSC Brennand, Gage Supported by private funds 361 14
Study 160 Contrasting causal microRNAs in forebrain and midbrain COS hiPSC neural cells iPSC Brennand 5R01MH101454-02 504 50
Study 163 Neuropsychiatric Genome-Scale and RDoC Individualized Domains (N-GRID) iPSC Isaac Kohane, Roy Perlis 5P50MH106933 416 400

In Progress*

Study Title Distributions PIs Grants Sites Target Sample Size GWAS Notes
Study 115 Exploring the Neuronal Phenotype of Autism Spectrum Disorders Using Induced Pluri iPSC Hallmayer, Dolmetsch R33MH087898 726 & 734 150
Study 165 Neural development of human induced pluripotent stem cells from schizophrenia patients iPSC Hongjun Song, Russell Margolis R21/R33MH087874 369 13

*Studies in progress includes those available for download for which some future action is required

Rutgers University Rutgers University USC Information Sciences Institute Washington University in St.Louis National Institute of Mental Health