Jump to content

Download Data

Depression

Explore Data

Depression 7.2

The Depression (DP) Distribution v7.2 was published on 2021-11-10. There are 12295 subjects, 8039 of whom have at least one biospecimen on record at the repository. In addition to case/control studies, the DP collection includes 2 family studies, one or more of which include families that are large and/or multigenerational.

Standard Data & Documentation

  • Distribution Bundle [ or ]: Standard files across disorders, containing demographic, diagnostic, and pedigree information. Sampled (formerly IBX) sample IDs (nrgr_bio_id) and consent level are also provided. Bundle includes data dictionaries.
  • Study Descriptions.
  • .
  • .

Additional Data Files

Genetic Data

Full Genome Genotyping

Genetic Data

Full Genome Genotyping

Genetic Data

Sequence - RNA

  • Case-control RNASeq data (Illuminal Hi Seq 2000) on 922 DGN subjects and GWAS data (Illumina Omni1-Quad) on 2,226 subjects. controls from GPC (Study 76/77), cases from GenRED2 (study 52) and DGN (study 88). The RNA sequencing data (BAM and FASTQ files) are available by request on multiple portable hard drives due to the large size of the files. To request shipment, please contact help@nrgr.on.spiceworks.com and reference your active access approval ID.
  • Separated from other Dataset 7 files due to size (17.6 GB)

Genetic Data

Targeted Genotyping

  • GenRED - SNPlex pool genotypes. 92 markers, 296 subjects (sib-pairs).
  • GenRED - 88 markers, 299 subjects.
Clinical Instruments

DIGS

Diagnostic Interview for Genetic Studies (DIGS) - The CSV-format DIGS interview files provided below are cleaned versions of those received from the original study investigators. While they retain the record layouts and variable naming of their respective DIGS versions, they have had invalid values corrected or removed, date fields converted to a standard format, and their various missing/ unknown values converted to standard textual metavalues in order to avoid misinterpretation. Further details on the cleaning that has been performed are included in the file "dp-digs-cleaning-readme.txt" included in the download. To download the original files as received from study investigators, use "original" links below.

Study 7 used version DIGS 3.0

Other

Genetic Data

Full Genome Genotyping

  • STAR*D Discovery - Cases only. PLINK files from Affymetrix 500K arrays on 964 subjects.
  • STAR*D Validation - Cases only. PLINK files from Affymetrix 5.0 arrays on 975 subjects.

Targeted Genotyping

Clinical Instruments

Clinical Trial

Clinical Instruments

Clinical Trial

Clinical Instruments

DIGS

Diagnostic Interview for Genetic Studies (DIGS) - The CSV-format DIGS interview files provided below are cleaned versions of those received from the original study investigators. While they retain the record layouts and variable naming of their respective DIGS versions, they have had invalid values corrected or removed, date fields converted to a standard format, and their various missing/ unknown values converted to standard textual metavalues in order to avoid misinterpretation. Further details on the cleaning that has been performed are included in the file "dp-digs-cleaning-readme.txt" included in the download. To download the original files as received from study investigators, use "original" links below.

Study 52 DIGS is a modified DIGS 3.0, specifically DIGS 3.01MD GenRED-II Apr 2006 v2, including the PLI from Kendler and the PTSD module of the SCID.

Clinical Instruments

Clinical Trial

Clinical Instruments

Other

  • Includes SCID, Hamilton Depression Rating Scale, Hamilton Depression Anxiety Rating Scale, QIDS-SR, and even some SNP data

Clinical Instruments

SCID

Study 7 — Genetics of Early-Onset Major Depression

  • GenRED - SNPlex pool genotypes. 92 markers, 296 subjects (sib-pairs).
  • GenRED - 88 markers, 299 subjects.

Study 18 — Sequenced Treatment Alternatives to Relieve Depression (STAR*D)

PGC — Psychiatric GWAS Consortium

MULTIPLE — Studies 7, 52 (GenRED)

Study 18 — Sequenced Treatment Alternatives to Relieve Depression (STAR*D)

  • STAR*D Discovery - Cases only. PLINK files from Affymetrix 500K arrays on 964 subjects.
  • STAR*D Validation - Cases only. PLINK files from Affymetrix 5.0 arrays on 975 subjects.

MULTIPLE — Studies 52 (GenRED), 76 (GPC), 77 (ICCBD), 88 (DGN)

  • Case-control RNASeq data (Illuminal Hi Seq 2000) on 922 DGN subjects and GWAS data (Illumina Omni1-Quad) on 2,226 subjects. controls from GPC (Study 76/77), cases from GenRED2 (study 52) and DGN (study 88). The RNA sequencing data (BAM and FASTQ files) are available by request on multiple portable hard drives due to the large size of the files. To request shipment, please contact help@nrgr.on.spiceworks.com and reference your active access approval ID.
  • Separated from other Dataset 7 files due to size (17.6 GB)

Diagnostic Interview for Genetic Studies (DIGS) - The CSV-format DIGS interview files provided below are cleaned versions of those received from the original study investigators. While they retain the record layouts and variable naming of their respective DIGS versions, they have had invalid values corrected or removed, date fields converted to a standard format, and their various missing/ unknown values converted to standard textual metavalues in order to avoid misinterpretation. Further details on the cleaning that has been performed are included in the file "dp-digs-cleaning-readme.txt" included in the download. To download the original files as received from study investigators, use "original" links below.

Study 7 — Genetics of Early-Onset Major Depression

Study 7 used version DIGS 3.0

Study 52 — Genetics of Early-Onset Major Depression (GenRED II)

Study 52 DIGS is a modified DIGS 3.0, specifically DIGS 3.01MD GenRED-II Apr 2006 v2, including the PLI from Kendler and the PTSD module of the SCID.

Study 7 — Genetics of Early-Onset Major Depression

Study 84 — Predictors of Antidepressant Treatment Response: The Emory CIDAR

  • Includes SCID, Hamilton Depression Rating Scale, Hamilton Depression Anxiety Rating Scale, QIDS-SR, and even some SNP data

Study 108 — Sustaining Remission of Psychotic Depression

Study 18 — Sequenced Treatment Alternatives to Relieve Depression (STAR*D)

Study 20 — Treatment of Adolescents with Depression (TADS) and Substance Use and Othe Outcomes Following Treatment for Adolecent Depression (SOFTAD)

Study 73 — Combining Medications to Enhance Depression Outcomes (CO-MED)

Study 83 — Incomplete Response in Late Life Depression: Getting to Remission (IRL GREY)

Study 88 — Depression Susceptibility Genes and Networks (DGN)