Depression

NOTE: The distribution refers to a collection of studies organized by disorder or theme (see FAQ).  It is important to note that not all individuals in the distribution have DNA available.

Given the major public health implications of identifying genes responsible for severe neuropsychiatric disorders, the National Institute of Mental Health (NIMH) has funded a Human Genetics Initiative. The goal of this Initiative is to establish a national resource of clinical data and biomaterials that are collected from individuals with autism, schizophrenia, bipolar I disorder, depression, obsessive-compulsive disorder, and other mental disorders. The NIMH Autism Genetics Initiative is supported by the Office of Human Genetics & Genomic Resources in NIMH's Division of Neuroscience and Basic Behavioral Science (DNBBS). Starting in 2001, data and biomaterials (cell lines and DNA samples) will be available to qualified investigators who study the genetics of autism, and may be accessed by following a set of instructions.

Data and biomaterials were collected in six projects that participated in the National Institute of Mental Health (NIMH) Genetics of Recurrent Early-Onset Depression (GenRED) project (1999-2009).  The Principal Investigators and Co-Investigators were:

  • New York State Psychiatric Institute, New York, NY, R01 MH060912, Myrna M. Weissman, Ph.D.; Johns Hopkins University, Baltimore, MD, R01 MH059552, J. Raymond DePaulo, M.D., and James B. Potash, M.D., M.P.H.; University of Pennsylvania, Philadelphia, PA (1999-2005), and Stanford University (2006-2009), R01 MH61686, Douglas F. Levinson, M.D. (GenRED coordinator); University of Iowa, Iowa City, IW, R01 MH059542e, Raymond R. Crowe, M.D., and William H. Coryell, M.D.; Rush University Medical Center, Chicago, IL, R01 MH059541-05, William A. Scheftner, M.D.; and University of Pittsburgh, Pittsburgh, PA (1999-2003), R01 MH060866, George S. Zubenko, M.D., Ph.D., and Wendy N. Zubenko, Ed.D., R.N., C.S.

Data and biomaterials were collected in six projects that participated in the National Institute of Mental Health (NIMH) Genetics of Recurrent Early-Onset Depression (GenRED) project. From 1999-2003, the Principal Investigators and Co-Investigators were:

  • New York State Psychiatric Institute, New York, NY, R01 MH060912, Myrna M. Weissman, Ph.D. and James K. Knowles, M.D., Ph.D.; University of Pittsburgh, Pittsburgh, PA, R01 MH060866, George S. Zubenko, M.D., Ph.D. and Wendy N. Zubenko, Ed.D., R.N., C.S.; Johns Hopkins University, Baltimore, R01 MH059552, J. Raymond DePaulo, M.D., Melvin G. McInnis, M.D. and Dean MacKinnon, M.D.; University of Pennsylvania, Philadelphia, PA, RO1 MH61686, Douglas F. Levinson, M.D. (GenRED coordinator), Madeleine M. Gladis, Ph.D., Kathleen Murphy-Eberenz, Ph.D. and Peter Holmans, Ph.D. (University of Wales College of Medicine); University of Iowa, Iowa City, IW, R01 MH059542, Raymond R. Crowe, M.D. and William H. Coryell, M.D.; Rush University Medical Center, Chicago, IL, R01 MH059541-05, William A. Scheftner, M.D.Rush-Presbyterian

A description of the design and clinical methods of the study can be found in:

  • Levinson DF, Zubenko GS, Crowe RR, DePaulo JR, Scheftner WS, Weissman MM, Holmans P, Zubenko WN, Boutelle S, Murphy-Eberenz K, MacKinnon D, McInnis MG, Marta DH, Adams P, Sassoon S, Knowles JA, Thomas J, Chellis J. Genetics of Recurrent Early-Onset Depression (GenRED): Design and Preliminary Clinical Characteristics of a Repository Sample for Genetic Linkage Studies. Am J Med Genet 119B:118-30, 2003.

List of Studies

Available for Download

Study Title Distributions PIs Grants Sites Target Sample Size GWAS Notes
Study 7 Genetics of Early-Onset Major Depression Depression Levinson, DePaulo, Sheftner, Crowe, Weissman, Zubenko R01MH060912 80-85 2238 653 in GenRED GWAS
Study 18 STAR*D; Treatment Resistant Depression Depression Rush N01MH090003 77 1942

962 in NIMH DP DS 2 STAR*D Discovery; 971 in NIMH DP 3 STARD V;

Study 20 TADS; Treatment of Adolescents with Depression Depression March 79
Study 52 Genetics of Early-Onset Major Depression (GenRED II) Depression DePaulo, Scheftner, Coryell, Weissman, Levinson, Lawson R01MH060912 280-286 1902

450 in GenRED GWAS; 776 in GenRED II GWAS;

Study 73 Combining Medications to Enhance Depression Outcomes (CO-MED) Depression Trivedi, Nierenberg, Gaynes, Husain, Preskorn, Kerber, Young, Gilmer, McGrath, Friedman, Zisook, Mitchell, Davis, Lesser, Leuchter, Shelton, Kornstein MH90003 (contract); Combining Medications to Enhance Depression Outcomes 287 650
Study 83 Incomplete Response in Late Life Depression: Getting to Remission Depression Reynolds, Lenze, Mulsant R01MH083660 277-279 500
Study 84 Predictors of Antidepressant Treatment Response: The Emory CIDAR; Predictors of Treatment Response, Relaps, and Recurrence in Major Depression Depression Mayberg, Craighead P50MH077083, R01MH080880 276 500
Study 88 Depression Susceptibility Genes and Networks: Expression, eQTL and GWAS Analysis Depression Levinson, Weissman, Potash RC2MH089916 621 1000 937 in GenREDII GWAS,922 in RNAseq
Study 108 Sustaining Remission of Psychotic Depression Depression Meyers (retired), Rothschild, Whyte, Flint 5U01MH062518, 5U01MH062624, 5U01MH062565, 4U01MH062446 630-633 400

In Progress*

Study Title Distributions PIs Grants Sites Target Sample Size GWAS Notes
Study 74 Examination of Genetic and GxE Effects in the Family and Community Health Studies (FACHS) Depression Philibert, Beach R01MH080898 133-134 800
Study 108 Sustaining Remission of Psychotic Depression Depression Meyers (retired), Rothschild, Whyte, Flint 5U01MH062518, 5U01MH062624, 5U01MH062565, 4U01MH062446 630-633 400

*Studies in progress includes those available for download for which some future action is required

Rutgers University Rutgers University USC Information Sciences Institute Washington University in St.Louis National Institute of Mental Health