Bipolar Disorder

NOTE: The distribution refers to a collection of studies organized by disorder or theme (see FAQ).  It is important to note that not all individuals in the distribution have DNA available.

Given the major public health implications of identifying genes responsible for severe neuropsychiatric disorders, the National Institute of Mental Health (NIMH) has funded a Human Genetics Initiative. The goal of this Initiative is to establish a national resource of clinical data and biomaterials that are collected from individuals with Alzheimer disease, schizophrenia, or bipolar I disorder (BP), in order to aid researchers in understanding the genetic bases of these disorders. The NIMH Bipolar Disorder Genetics Initiative is supported by the Office of Human Genetics & Genomic Resources in NIMH's Division of Neuroscience and Basic Behavioral Science (DNBBS). Since 1996, data and biomaterials (cell lines and DNA samples) have been available to qualified investigators who study the genetics of BP, and may be accessed by following a set of instructions.

From 1991-98, BP pedigrees were ascertained by three extramural sites (Indiana University, Johns Hopkins University, and Washington University) and one intramural site (NIMH Clinical Neurogenetics Branch). In 1998, NIMH issued a Request for Applications (MH-98-010) to solicit applications for collaborative research projects to collect large pedigree samples and conduct molecular genetic analyses on schizophrenia, BP, and early-onset recurrent unipolar depression. Data and biomaterials collected and produced in these projects will augment existing resources in the NIMH BP Genetics Initiative that are distributed to the scientific community.

Two large collaborative BP projects were funded under MH-98-010. One consists of nine extramural sites (Indiana University, Johns Hopkins University, Rush-Presbyterian-St. Lukes Medical Center, University of California - Irvine, University of California - San Diego, University of Chicago, University of Iowa, University of Pennsylvania, and Washington University) and one intramural site (NIMH-IRB), and the other consists of two sites (Columbia University and Hadassah-Hebrew University Medical Center in Jerusalem, Israel). Establishment of DSM-III-R and DSM-IV diagnoses is made following a systematic and comprehensive examination of multiple sources of available information obtained from relatives, medical records, and direct assessment using the Diagnostic Interview for Genetic Studies (DIGS). Nuclear and extended pedigrees have been ascertained in which there are at least two individuals affected with BP who are first-degree biological relatives.

Anonymous data in the NIMH BP Genetics Initiative on family structure, age, sex, vital status, psychopathology, diagnosis, and other clinically relevant information, as well as lymphoblastoid cell lines and DNA, are stored, maintained and distributed by the NIMH Center for Genetic Studies. The Center is operated under an NIMH grant to Rutgers University and subcontracted to Washington University.

List of Studies

Available for Download

Study Title Distributions PIs Grants Sites Target Sample Size GWAS Notes
BP 0 Linkage Studies of Bipolar Disorder Bipolar Disorder Nurnberger, Reich, DePaulo, Gershon 5U01MH046282, 5U01MH046280, 5U01MH046274 10-13 1353

175 in dbGaP BP GAIN; 112 in NIMH BP-DS11 phase1; 174 in NIMH BP-DS11 phase2;

Study 1 A Collaborative Genomic Study of Bipolar Disorder Bipolar Disorder Berrettini, Byerley, Coryell, DePaulo, Gershon, Kelsoe, Nurnberger, Reich, Sheftner, Murphy R01MH059545 20-29 1768

387 in dbGaP BP GAIN;  280 in NIMH BP DS11 phase1; 429 in NIMH BP DS11 phase2;

Study 2 Molecular Genetics of Bipolar Disorder Bipolar Disorder Baron R01MH059602 Site 15-US; Site 16-Israel 843

72 in GWAS Pritzker 1, 94 in GWAS Pritzker 2

Study 8 Genetic Analysis of Bipolar Disorder Bipolar Disorder Pato R01MH058693 38 223
Study 19 STEP-BD; Treatment of Bipolar Disorder Bipolar Disorder Sachs, Nimgaonkar N01MH080001 14, 78, 86, Site 88-Controls 2365

847 cases and 453 ctls in STEP-BD GWAS; 486 in NIMH Controls DS 1;  105 in dbGap NIMH-CTL Exome;

Study 40 Bipolar Genome Study (BiGS) Bipolar Disorder Schetner, Gershon, McMahon, Kelsoe, Nurnberger, McInnis, Berrettini, Byerley, Coryell, Lawson, Rice, Univ. of Michigan P50CA89392 from the National Cancer Institute; K02DA021237 from the National Institute of Drug Abuse 170-181 3934

853 in dbGaP BP GAIN

Study 48 A study of Bipolar Disorder Bipolar Disorder McMahon, DePaulo, Gershon 186-188 642
Study 49 Genetics of Bipolar Disorder in Latino Populations Bipolar Disorder Escamilla, Medoza, Paso, Paez, Jerez, Raventos, Nicolini, Ontiveros R01MH069856 190-197 2688
Study 55 Adolescents at High Risk for Familial Bipolar Disorder Bipolar Disorder Nurnberger, Kastelli, McInnis, Reich R01MH068009 750-753 374
Study 71 Bipolar Endophenotypes in Population Isolates Bipolar Disorder Freimer, Macaya, Ospina-Duque R01MH075007 198-199 560
Study 75 Lithium Use for Bipolar Disorder: A Randomized Controlled Effectiveness Trial (LiTMUS) Bipolar Disorder Nierenberg, Ostacher,Iosifescu, Thase, Ketter, Bowden, Calabrese, Friedman Lithium Use for Bipolar Disorder: A Randomized Controlled Effectiveness Trial 189 193
Study 77 International Cohort Collection for Bipolar Disorder Bipolar Disorder Smoller, Sklar, Pato, Knowles, Bromet, Rapaport, Buckley, Escamilla, Morley, Dewan, Lehrer, Marder, Perkins, Malaspina, Nicolini R01MH085542 252, 270, 272-275, 304-312, 845 8947
Study 123 Acute Psychotherapy for Bipolar II Depression Bipolar Disorder Swartz R01MH084831 432 38
Study 140 Genome Sequencing in Extended Bipolar Pedigrees Bipolar Disorder Fremier, Jaramillo, Macaya 3R01MH095454-02S1 435-436 2000

In Progress*

Study Title Distributions PIs Grants Sites Target Sample Size GWAS Notes
Study 48 A study of Bipolar Disorder Bipolar Disorder McMahon, DePaulo, Gershon 186-188 642
Study 77 International Cohort Collection for Bipolar Disorder Bipolar Disorder Smoller, Sklar, Pato, Knowles, Bromet, Rapaport, Buckley, Escamilla, Morley, Dewan, Lehrer, Marder, Perkins, Malaspina, Nicolini R01MH085542 252, 270, 272-275, 304-312, 845 8947
Study 156 Transferred from Coriell Collection Bipolar Disorder DeLisi, Gershon Site 735 (BP); Site 736 (SZ) 2500

*Studies in progress includes those available for download for which some future action is required

Rutgers University Rutgers University USC Information Sciences Institute Washington University in St.Louis National Institute of Mental Health