Support > FAQ

  1. What is a Distribution and what do the numbers mean?
  2. What is the difference between NRGR and dbGaP? NDA?
  3. I have lost my password, how do I reset it? I don't remember my username, how do I get it back?
  4. How do I obtain access to data and biomaterials?
  5. Are non-academic institutions allowed to apply for access to data and biomaterials?
  6. I’ve requested access to data and biomaterials via the Access Approval System. The status is “pending” – when can I expect confirmation of approval?
  7. I've been granted access to data and biomaterials. What's next?
  8. I am the PI of an ongoing NRGR Study. How to I obtain access to my own biosamples?
  9. I've been granted access to data and biomaterials. How do I order biosamples?
  10. I have access to an older version of a Distribution. Why don’t I have access to the current version? Why would I want access to the new version?
  11. I have signed a Distribution Agreement for a disorder (example: Schizophrenia) and was granted access. Now, I would like to obtain access to different data and/or biomaterials (example: Controls). Do I sign an amendment or another Distribution Agreement?
  12. How do I submit data to the repository?
  13. I’m not ready to submit all of my data, but want to test a subset of my submission. Can I do that?
  14. I’m having trouble interpreting the results of my AutoQC failure. How can I get assistance?
  15. I tried to submit to AutoQC, but received the message “Workflow Generator Failed” or “Workflow Generator Error” – what does that mean?
  16. I had a successful AutoQC run and clicked the button to submit my data for manual QC. What is next? How will I know when my data is released?

  1. What is a Distribution and what do the numbers mean?

    A distribution is a collection of studies, with access granted for the whole collection. They are organized by disorder (e.g., Schizophrenia, Bipolar, etc.) or by theme (e.g., controls or iPSCs). Typically, the subjects are consented to allow research for that disorder or related conditions, or for general research use.

    The difference between Distribution 2.0 and 3.0 is that at least one new study has been added, so there is an added acknowledgement in the Distribution Agreement and Amendment to indicate this. If a user has access to Distribution 2.0, they would have to process an amendment to indicate this before getting access to Distribution 3.0. A change in the number after the decimal point (ie 2.2) indicates changes or additions without adding new studies, so an Amendment is not needed.

  2. What is the difference between NRGR and dbGaP? NDA?

    The NIMH Repository and Genomics Resource is one of several data repositories funded by NIH. Different data repositories specialize in managing different types of data, and data from a single individual may be deposited into multiple different repositories. The NIH, guided by the new strategic plan for data science, is working to optimize integration between repositories to maximize the utility of all collected data, but currently researchers may need to navigate several repositories to obtain all available data on a given subject:

    The NIMH Repository and Genomics Resource (NRGR) is the only repository that holds and distributes the biomaterials (e.g., DNA, RNA, cell lines) associated with NIMH genetic studies. At a minimum we provide basic demographic and diagnostic data on all our biosamples; for most of our biosamples we have detailed diagnostic data, frequently item level data on major assessment instruments, available on our site. We also have genotype, DNA sequence, and gene expression data associated with a subset of our biosamples.

    The NIMH Data Archive (NDA) holds clinical, imaging, and neurosignal data on subjects from a wide range of NIMH studies. Only a fraction of the studies in the NDA are in the NRGR, as the NDA includes very many studies without a genetic component. Since the NRGR predates the NDA, some studies in the NRGR are not present in the NDA. Components of the NDA include the National Database for Autism Research (NDAR), the National Database for Clinical Trials Related to Mental Illness (NDCT), the Research Domain Criteria Database (RDoCdb), the Adolescent Brain Cognitive Development Study (ABCD), The Connectome Coordination Facility (CCF), and the Osteoarthritis Initiative (OAI). NDAR also includes genotype, sequence, and gene expression data. Subjects present in both the NRGR and the NDA are associated by lists linking the IDs from the two repositories.

    The database of Genotypes and Phenotypes (dbGAP) is an NIH-wide repository of phenotypic and genomic data. Only a fraction of the studies in dbGAP are in the NRGR, as dbGAP includes many studies that are not related to psychiatric illness. While dbGAP does include phenotypic data, those data are frequently less detailed than the phenotypic data available on the same subjects from the NRGR. Subjects present in both the NRGR and dbGAP are associated by lists linking the IDs from the two repositories.

  3. I have lost my password, how do I reset it? I don't remember my username, how do I get it back?

    You must provide your username for a link to reset your password to be mailed to you. If you have forgotten your username, provide your account email address and we will email the username to you. Reset your forgotten password, or retrieve your forgotten username

  4. How do I obtain access to data and biomaterials?

    Access is available to qualified researchers through a simple online Access Approval process. Access approval requires the researcher’s institutional approval and can take several weeks for the Data Access Committee to review and confirm. Review the complete instructions for access approval.

  5. Are non-academic institutions allowed to apply for access to data and biomaterials?

    Yes. Non-academic institutions must undergo the same access approval application process as academic institutions.

  6. I’ve requested access to data and biomaterials via the Access Approval System. The status is “pending” – when can I expect confirmation of approval?

    Access Approval requires complete review by the Data Access Committee. There is a queue of prior requests, and review can take several weeks or longer, assuming the application is complete. It is always advisable to respond promptly to NIMH queries about your application materials to keep the process moving.

  7. I've been granted access to data and biomaterials. What's next?

    After access approval, the user must login using the same account under which they were granted access, and navigate to the approved download page https://www.nimhgenetics.org/available_data/. To perform queries on individual level data after approval, navigate to https://explorer.nimhgenetics.org/

  8. I am the PI of an ongoing NRGR Study. How to I obtain access to my own biosamples?

    To order biomaterials, you will need to provide your NIMH Study ID number, the ind_id and RUID of the desired materials, along with identifying the quantity needed for your approved goals.

    Ordering biomaterials.

  9. I've been granted access to data and biomaterials. How do I order biosamples?

    To order biomaterials, you will need to provide your access approval number, the ind_id and RUID of the desired materials, along with identifying the quantity needed for your approved goals.

    Ordering biomaterials.

  10. I have access to an older version of a Distribution. Why don’t I have access to the current version? Why would I want access to the new version?

    Every time a new study is added to a collection, you must sign an amended access agreement to gain access to the updated collection. You do not lose access to the previous version until your original access approval expires. Updates to studies you already can access will be available to you without an amendment.

    Sign and submit the amendment to the Genomics Resources Program Office for approval. Amendments are available on each distribution download page: Available Data > Disorder/Collection > Release Notes > Amendment.

  11. I have signed a Distribution Agreement for a disorder (example: Schizophrenia) and was granted access. Now, I would like to obtain access to different data and/or biomaterials (example: Controls). Do I sign an amendment or another Distribution Agreement?

    You must sign a new Distribution Agreement (not an amendment) in order to gain access to data and biomaterials for a disorder to which you have not previously been granted access.

  12. How do I submit data to the repository?

    Instructions for data submissions.

    The NRGR Communications & Curation team is available for personalized training sessions in advance of data submission. If you are preparing to submit data, please reach out to help@nrgr.on.spiceworks.com to schedule a training session. We encourage studies to train on the submission process as early in the study as possible.

  13. I’m not ready to submit all of my data, but want to test a subset of my submission. Can I do that?

    Yes! We encourage studies to use the AutoQC system to test interim data before their final submission is due, to familiarize themselves with the process and error messages, and also to catch data entry errors in advance of publication.

  14. I’m having trouble interpreting the results of my AutoQC failure. How can I get assistance?

    Submit a helpdesk ticket to help@nrgr.on.spiceworks.com, and include your study ID and AutoQC submission ID in the helpdesk ticket. Someone from the NRGR curation team will review your questions. If necessary, we can schedule a webex session to guide you through corrections.

  15. I tried to submit to AutoQC, but received the message “Workflow Generator Failed” or “Workflow Generator Error” – what does that mean?

    “Workflow Generator Failed” – occurs when the component parts of a submission are faulty or incomplete. Common causes include dictionaries with improper formatting (_phen_dd and/or _dx), especially when missing columns. Check that your dictionary is of the proper format.

    “Workflow Generator Error” – this may indicate a bug in the AutoQC system.

    Please notify us via the helpdesk help@nrgr.on.spiceworks.com when one of these errors is generated, including a screenshot and the attempted submission .zip package.

  16. I had a successful AutoQC run and clicked the button to submit my data for manual QC. What is next? How will I know when my data is released?

    It is very likely that an NRGR curator will reach out to you with clarifying questions and/or requests for updates, and will guide you through the re-submission process if necessary. The Manual QC process includes expert review of your study-defined data dictionaries, confirmation that your submission is complete per your NIMH-approved Data Sharing Plan, and other checks based on the type of data submitted.

    Before your data is released, the NRGR curation team will inform you of the final submission package being released and the intended release date via email.

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